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Activation of glucokinase in rat Primary hepatocytes assessed as fold increase in glycogen synthesis at 10 uM incubated for 30 mins using [U14C]-D-glucose as substrate by Microbeta TriLux luminescence counter analysis
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of recombinant human glucokinase assessed as increase in maximal activation by measuring accumulation of NADH at 60 uM in presence of S0.5 of glucose and NAD by plate reader analysis
Assay data:1 Tested
Activation of recombinant human glucokinase assessed as increase in maximal activation by measuring accumulation of NADH in presence of S0.5 of glucose and NAD by plate reader analysis
Assay data:14 Active, 10 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at glucokinase (unknown origin) assessed as fold increase at 10 uM by luciferase reporter gene assay
Inhibition of human recombinant GCK (1 to 473 residues) using myelin basic protein as substrate in presence of ATP incubated for 40 mins by radiometric based scintillation method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
GCK(h) Kinase panel
SummaryRelated BioAssays by Target
Inhibition of GCK (unknown origin) at 1 uM
Activation of human glucokinase assessed as increase rate of glucose turnover
Assay data:2 Tested
Activation of human glucokinase assessed as decrease in glucose Km
Activation of recombinant mouse full length liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins in presence of 12 mM glucose by plate reader analysis relative to control
Activation of recombinant mouse full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 12 mM glucose by plate reader analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins in presence of 2 mM glucose by plate reader analysis relative to control
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 2 mM glucose by plate reader analysis
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins in presence of 5 mM glucose by plate reader analysis relative to control
Displacement of fluorescent labeled derivative from recombinant human hepatic glucokinase incubated for 30 mins in presence of 12 mM glucose by fluorescent polarization assay
Activation of recombinant full length human liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins by plate reader analysis relative to control
Assay data:26 Tested
Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysis
Assay data:26 Active, 25 Activity ≤ 1 µM, 26 Tested
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 5 mM glucose by plate reader analysis
Inhibition of human recombinant GCK assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
In Vitro Activity Assay from US Patent US10633348: "Methods to treat lymphoplasmacytic lymphoma"
Assay data:14 Active, 12 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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