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Inhibition of SLC26A3-mediated Cl-/ I- exchange in human HEK293 cells measured by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of mouse Slc26a3 transfected in rat FRT cells at 10 uM preincubated with forskolin, 8-Br-cGMP and PMA and measured by fluorescence assay relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of mouse Slc26a3 transfected in rat FRT cells preincubated with forskolin, 8-Br-cGMP and PMA and measured by fluorescence assay
Assay data:44 Active, 12 Activity ≤ 1 µM, 51 Tested
Inhibition of myc-tagged mouse Slc26a3 expressed in COS7 co-expressing EYFP-HIF assessed as effect on SCN(-) gradient at 25 uM by YFP-based fluorescence quenching assay
Inhibition of human SLC26A3 expressed in COS7 co-expressing EYFP-HIF assessed as reduction in SCN gradient
Inhibition of mouse slc26a3 expressed in FRT cells co-expressing EYFP-H148Q/I152L/F46L assessed as reduction in protein-mediated chloride/bicarbonate exchange by measuring decrease in cytoplasmic alkalinization by BCECF probe-based fluorescence assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse slc26a3 expressed in FRT cells co-expressing EYFP-H148Q/I152L/F46L assessed as reduction in protein-mediated chloride/iodide exchange preincubated for 10 mins followed by NaI-substituted PBS addition and measured by YFP-based fluorescence assay
Assay data:22 Active, 14 Activity ≤ 1 µM, 45 Tested
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