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Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Glutathione Peroxidase Activity Assay from Article 10.3109/14756366.2012.688042: "Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach."
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of GPx1 using gultathione as substrate at 50 uM by glutathione reductase-coupled assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GPx1 using gultathione as substrate by glutathione reductase-coupled assay
Inhibition of GPx1 assessed as increase in intracellular oxidative stress at 250 uM by DCHF-DA-based flow cytometric analysis
Inhibition of glutathione peroxidase 1 in human bortezomib-resistant GUMBUS cells assessed as decrease in bortezomib resistance ratio at 25 uM after 72 hrs by MTT assay
Inhibition of glutathione peroxidase 1 in human etoposide-resistant GUMBUS cells assessed as decrease in etoposide resistance ratio at 25 uM after 72 hrs by MTT assay
Inhibition of glutathione peroxidase 1 in human methotrexate-resistant GUMBUS cells assessed as decrease in methotrexate resistance ratio at 25 uM after 72 hrs by MTT assay
Inhibition of glutathione peroxidase 1 in human cisplatin-resistant DOGUM cells assessed as decrease in cisplatin resistance ratio at 25 uM after 72 hrs by MTT assay
Inhibition of glutathione peroxidase 1 in human cisplatin-resistant GUMBUS cells assessed as decrease in cisplatin resistance ratio at 25 uM after 72 hrs by MTT assay
Inhibition of glutathione peroxidase 1 in human bortezomib-resistant DOGUM cells assessed as decrease in bortezomib resistance ratio at 25 uM after 72 hrs by MTT assay
Inhibition of glutathione peroxidase 1 in human etoposide-resistant DOGUM cells assessed as decrease in etoposide resistance ratio at 25 uM after 72 hrs by MTT assay
Inhibition of glutathione peroxidase 1 in human methotrexate-resistant DOGUM cells assessed as decrease in methotrexate resistance ratio at 25 uM after 72 hrs by MTT assay
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