Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Homogeneous Time-Resolved Fluorescence (HTRF) Binding Assay from US Patent US20240083890: "MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1"
Assay data:31 Active, 27 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
homogeneous time-resolved fluorescence (HTRF) binding assay from US Patent US20240067660: "MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS"
Assay data:36 Active, 25 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
Caspase Glo MOLP-8 assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
HTRF (MCL1)
Assay data:1 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of N-terminal GST-tagged human recombinant Mcl-1 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay
Assay data:26 Active, 17 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysis
Assay data:16 Active, 12 Activity ≤ 1 µM, 17 Tested
Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as binding constant (Kon) by SPR analysis
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as binding constant (Koff) by SPR analysis
Inhibition of his-tagged human recombinant Bcl-2 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay
Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested
Binding affinity to Mcl-1 (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescence polarization assay
Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of FITC-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) incubated for 20 mins by fluorescence polarization assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assay
Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant Mcl-1 (unknown origin) by fluorescence polarization-based competitive binding assay
Inhibition of Mcl-1 (unknown origin)
Inhibition of Bfl-1/Bim (unknown origin) incubated for 30 mins by TR-FRET assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Bfl-1/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of Bfl-1/Bim (unknown origin) by fluorescence polarization assay
Displacement of fluorescein tagged Bak BH3 peptide from MCL-1 (172 to 327 residues) (unknown origin) by fluorescence polarization competition assay
Assay data:1 Active, 1 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on