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Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b SETD7
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (SPR measurement) EUB0000196bCl SETD7
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (ITC) EUB0000196bCl SETD7
Selectivity interaction (Methyltransferase panel (radioactive enzyme assay)) EUB0000216b SETD7
Selectivity interaction (HMT panel) EUB0000194b SETD7
Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b SETD7
Affinity Biochemical interaction (Scintillation proximity assay (SPA) ) EUB0000196bCl SETD7
Affinity On-target Cellular interaction (Immunoblot (increase in nuclear YAP levels by treatment of MEFs (from Setd7+/+ mice) with 10 M PFI-2)) EUB0000196bCl SETD7
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human SET7/9 at 10 uM by radioisotope-based filter binding assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human his-tagged SET7/9 (2 to 366 residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay
Inhibition of SET7 (unknown origin) measured by AlphaLISA-based biochemical assay
Inhibition of SET7 (unknown origin)
Assay data:2 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of N-terminal and GST-tagged C-terminal His-tagged SET7/9 (2 to 366 residues) (unknown origin) expressed in Escherichia coli at 1 uM using 3H-SAM as a substrate relative to control
Inhibition of human recombinant full length N-terminal GST-tagged and C-terminal his-tagged SET7/9 (2 to 366 residues) expressed in Escherichia coli at 50 uM using [3H]-SAM and histone H3.3 as substrate by scintillation/filter plate assay relative to control
Inhibition of human recombinant full length N-terminal GST-tagged and C-terminal his-tagged SET7/9 (2 to 366 residues) expressed in Escherichia coli at 10 uM using [3H]-SAM and histone H3.3 as substrate by scintillation/filter plate assay
Inhibition of His-SETD7 (unknown origin) measured at 100 uM incubated for 10 mins in presence of H3-21 peptide by fluorescence-based SAHH-coupled assay
Inhibition of SETD7 (unknown origin) at 1 to 10 uM
Assay data:2 Tested
HMT Assay from Article 10.1038/nchembio.2304: "An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of SET7/9 (unknown origin) at 10 uM using SAM as substrate measured up to 960 mins by AlphaScreen microplate reader assay relative to control
Inhibition of recombinant human full length C-terminal His-tagged SETD7 expressed in Escherichia coli using core histone as substrate at 10 uM by radiometric HotSpot assay relative to control
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