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Inhibition of sEH in IFNgamma treated human BxPC-3 cells lysate assessed as reduction in kynurenine production at 10 uM pretreated with IFNgamma for 24 hrs followed by compound addition and measured after 45 mins
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of sEH in IFNgamma induced human HeLa cells assessed as reduction in kynurenine level at 10 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of sEH in IFNgamma induced human HeLa cells assessed as reduction in kynurenine level
Assay data:3 Tested
Inhibition of sEH in IFNgamma induced human HAP1 cells assessed as reduction in kynurenine production
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of sEH in IFNgamma induced human HAP1 cells assessed as reduction in kynurenine production at 500 nM
Displacement of tracer from NanoLuc fused sEH in HEK293T cells assessed as decrease in BRET ratio incubated for 5 hrs by NanoBRET assay
Binding affinity to sEH in human Jurkat cells assessed as change in melting temperature at 10 uM incubated for 15 mins by CETSA
Inhibition of recombinant human sEH phosphatase activity at 10 uM incubated for 5 mins by microplate reader analysis
Assay data:1 Active, 3 Tested
Inhibition of recombinant human sEH using fluorogenic PHOME as substrate measured after 10 sec by microplate reader analysis
Binding affinity to recombinant human sEH assessed as change in thermal temperature at 10 uM incubated for 10 mins by nanoDSF method
Displacement of 2-(5-(1-amino-3,6,9,12-tetraoxapentadec-14-yn-15-yl)-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl)-N-cycloheptylacetamide from sEH in human HeLa cells at 10 uM preincubated for 1 hr followed by 2-(5-(1-amino-3,6,9,12-tetraoxapentadec-14-yn-15-yl)-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl)-N-cycloheptylacetamide addition by immunoblotting analysis
Assay data:1 Active, 1 Tested
Inhibition of sEH (unknown origin)
Potency index, ratio of t-TUCB IC50 to test compound IC50 for inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate assessed as 6-methoxynaphthaldehyde product formation preincubated with compound for 10 mins followed by substrate addition and measured by fluorescence based analysis
Potency index, ratio of t-TUCB IC50 to test compound IC50 for inhibition of recombinant mouse soluble epoxide hydrolase using PHOME as substrate assessed as 6-methoxynaphthaldehyde product formation preincubated with compound for 10 mins followed by substrate addition and measured by fluorescence based analysis
Assay data:2 Tested
Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate assessed as 6-methoxynaphthaldehyde product formation preincubated with compound for 10 mins followed by substrate addition and measured by fluorescence based analysis
Assay data:54 Active, 31 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 54 Tested
Inhibition of recombinant mouse soluble epoxide hydrolase using PHOME as substrate assessed as 6-methoxynaphthaldehyde product formation preincubated with compound for 10 mins followed by substrate addition and measured by fluorescence based analysis
Assay data:54 Active, 46 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 54 Tested
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of human recombinant sEH expressed in baculovirus infected Sf9 insect cells assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min followed by substrate addition and measured after 60 mins by fluorescence based analysis
Assay data:20 Active, 19 Activity ≤ 1 µM, 21 Tested
Inhibition of human recombinant sEH
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
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