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Inhibition of ERp57 (unknown origin) reductase activity assessed as inhibition of PDI/DTT-mediated cleavage of disulfide bond in insulin in the presence of DTT incubated for 40 mins by spectrophotometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to PDIA3 in human DOHH-2 cells by MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to PDIA3 in human MDA-MB-453 cells at 10 uM measured after 6 hrs in presence of 100 uM PES by pull-down assay
Binding affinity to PDIA3 in human DOHH-2 cells at 10 uM measured after 6 hrs in presence of 100 uM PES by pull-down assay
Binding affinity to PDIA3 in human MDA-MB-453 cells measured after 6 hrs by pull-down assay
Binding affinity to PDIA3 in human DOHH-2 cells measured after 6 hrs by pull-down assay
Inhibition of N-(4-(5,5-Difluoro-1,3,7,9-tetramethyl-5H-4(Gamma4),5(Gamma4)-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl))-N-(2-(4-((6-hydroxybenzo[d]-[1,3]dioxol-5-yl)(piperidin-1-yl)methyl)benzamido)ethyl)-benzamide binding to recombinant PDIA3 (unknown origin) measured after 24 hrs by PAGE analysis
Inhibition of PDIA3 (unknown origin) at 40 uM using bovine insulin as substrate preincubated for 1 hr followed by substrate addition
Assay data:2 Active, 2 Tested
Inhibition of PDIA3 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr and measured by insulin reduction assay
Assay data:1 Active, 3 Tested
Binding affinity to PDIA3 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Inhibition of ERP57 (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay
Assay data:9 Tested
SummaryRelated BioAssays by Target
Selectivity Screen to determine compound activity against other thiol isomerases: ERp57 Measured in Biochemical System Using Plate Reader - 2137-09_Inhibitor_Dose_DryPowder_Activity
Assay data:12 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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