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Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assay
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (Kinobeads competition assays) EUB0000614a MAP4K2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000238b MAP4K2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Western Blot (inhibition in IL-1-induced phosphorylation of MAPK14)) EUB0000238b MAP4K2
Inhibition of MAP4K2 (GCK) (unknown origin) at 0.1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MAP4K2 (GCK) (unknown origin) at 1 uM relative to control
Inhibition of wild-type human partial length MAP4K2 (M1 to G318 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control
Inhibition of human wild type partial length MAP4K2 (M1 to G318 residues) expressed in mammalian expression system assessed as remaining activity at 1 uM by Kinomescan assay relative to control
MAP4K2 DiscoveRx kinase panel
Binding affinity to human MAP4K2 assessed as dissociation constant by KdELECT Discover assay
Inhibition of human MAP4K2 at 2 uM by competition binding assay relative to control
KinomeScan assay: inhibition of MAP4K2
Assay data:108 Tested
MAP4K2 ProQinase selectivity panel
MAP4K2 (GCK) Kinase screen
MAP4K2 Invitrogen selectivity data (BI)
mitogen-activated protein kinase kinase kinase kinase 2 Millipore kinase panel
MAP4K2 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of recombinant human GCK (1 to 473 residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MAP4K2 (unknown origin) assessed as residual activity measured at 1 uM
Assay data:3 Tested
Inhibition of human MAP4K2 (M1 to G318 residues) expressed in mammalian expression system at 2000 nM by KINOMEscan assay relative to control
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