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Homogeneous Time-Resolved Fluorescence (HTRF) from US Patent US20240199625: "BICYCLIC HETEROCYCLIC FGFR4 INHIBITOR, PHARMACEUTICAL COMPOSITION AND PREPARATION COMPRISING SAME, AND APPLICATION THEREOF"
Assay data:8 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kinase Assay from US Patent US20240109865: "INDAZOLE COMPOUNDS AS KINASE INHIBITORS"
Assay data:359 Active, 363 Activity ≤ 1 µM, 363 Tested
Mobility-Shift Assay from US Patent US11912663: "Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses"
Assay data:14 Active, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
FGFR3 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
FGFR2 SGC Tm panel (DSF)
FGFR1 SGC Tm panel (DSF)
FGFR1 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of FGFR2 (unknown origin) at 10 uM by biochemical hotspot kinase assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FGFR3 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of FGFR1 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of FGFR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of His-tagged human recombinant FGFR2 (403 to 822 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay
Inhibition of FGFR4 in human Hep3B cells assessed as reduction in ERK phosphorylation by Western blot analysis
Inhibition of FGFR4 in human Hep3B cells assessed as reduction in AKT phosphorylation by Western blot analysis
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