Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Detecting inositol monophosphate production from US Patent US11912693: "Compounds for modulating S1P1 activity and methods of using the same"
Assay data:8 Active, 32 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of S1PR2 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to S1PR2 (unknown origin) assessed as dissociation constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at S1PR2 in human SW620/5-FU cells assessed as reduction of DPD-catalyzed 5-FU degradation by measuring intracellular 5-FU level at 20 uM measured after 24 hrs by HPLC-UV analysis (Rvb = 2.57 uM)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to S1PR2 (unknown origin) by SPR assay
Assay data:33 Active, 7 Activity ≤ 1 µM, 34 Tested
Displacement of [32P]S1P from human recombinant S1PR2 incubated for 60 mins by competitive binding assay based scintillation counter
Assay data:15 Active, 30 Activity ≤ 1 µM, 30 Tested
Inhibition of FBAL stimulated S1PR2 in human SW620/5-FU cells incubated for 72 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to S1PR2 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis
Assay data:26 Active, 7 Activity ≤ 1 nM, 41 Activity ≤ 1 µM, 41 Tested
Antagonist activity at S1P2 (unknown origin)
Antagonist activity against human S1P2 assessed as inhibition of beta-arrestin 2 recruitment
Antagonist activity at human S1P2 in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hrs in presence of 2% HSA by ELISA
Assay data:13 Active, 11 Activity ≤ 1 µM, 13 Tested
Antagonist activity at human S1P2 in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hrs by ELISA
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Displacement of sphingosine D-erythro [3-3H] I- phosphate from human S1P2 receptor expressed in CHO cell membrane
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding
Assay data:30 Active, 28 Activity ≤ 1 µM, 32 Tested
Agonist activity at human S1P2 receptor expressed in CHO cells assessed as increase in calcium flux
Assay data:7 Tested
Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as inhibition of calcium flux
Assay data:28 Active, 27 Activity ≤ 1 µM, 33 Tested
Competition Binding Assay from US Patent US11034691: "Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders"
Assay data:355 Active, 260 Activity ≤ 1 µM, 366 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Binding Assay from US Patent US10676467: "Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof"
Assay data:55 Active, 1 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 58 Tested
Fluorescence-Based Assay from US Patent US8975409: "Phenyl derivative"
Assay data:9 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
TBD from US Patent US10323029: "Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders"
Assay data:354 Active, 260 Activity ≤ 1 µM, 365 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on