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Inhibition of Escherichia coli N-terminal hexahstidine-tagged TS at 500 uM by steady-state kinetic analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Escherichia coli N-terminal hexahistidine tagged TS assessed as change in entropy at 0.2 mM by isothermal titration calorimetry method
Assay data:1 Tested
Binding affinity to Escherichia coli N-terminal hexahistidine tagged TS assessed as change in gibbs free energy at 0.2 mM by isothermal titration calorimetry method
Binding affinity to Escherichia coli TN-terminal hexahistidine-tagged TS at 20 uM by biolayer interferometry assay
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Escherichia coli N-terminal hexahstidine-tagged TS by steady-state kinetic analysis
Inhibition Assay from US Patent US9422297: "Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof"
Assay data:13 Active, 6 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from Article 10.1002/cbic.200700524: "Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases."
Assay data:12 Active, 1 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay from Article 10.1016/j.chembiol.2003.11.012: "Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase."
Assay data:7 Active, 4 Activity ≤ 1 µM, 7 Tested
Inhibition Assay from Article 10.1016/S1074-5521(01)00067-9: "Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase."
Assay data:2 Active, 7 Tested
Thymidylate Synthase (TS) Assay from Article 10.1021/jm900490a: "Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents."
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
Thymidylate Synthase (TS) Assay from Article 10.1021/jm701052u: "Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors."
Assay data:17 Active, 12 Activity ≤ 1 µM, 19 Tested
Thymidylate Synthase (TS) Assay from Article 10.1021/jm058276a: "Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1)."
Assay data:12 Active, 7 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Dihydrofolate Reductase (DHFR) Assay from Article 10.1021/jm058234m: "Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and a"
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Thymidylate Synthase (TS) Assay from Article 10.1021/jm051187d: "Antibacterial agent discovery using thymidylate synthase biolibrary screening."
Assay data:17 Active, 9 Activity ≤ 1 µM, 19 Tested
Thymidylate Synthase (TS) Assay from Article 10.1107/S0907444905022638: "The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
Inhibition of Escherichia coli thymidylate synthase A
Assay data:23 Active, 2 Activity ≤ 1 µM, 45 Tested
Inhibition of Escherichia coli thymidylate synthase A at 54 uM
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