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Inhibition of recombinant LSD2 (unknown origin) at 10 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human LSD2
Inhibition of human LSD2 using H3K4Me2 peptide as substrate incubated for 60 min by peroxidase-coupled method
Inhibition of recombinant human full length LSD2 using biotinylated H3K4Me2 peptide as substrate by TR-FRET assay
Assay data:21 Active, 3 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human LSD2 in human CCRF-CEM cells assessed as fold increase in H3K4me2 level at 20 uM after 24 hrs by western blot analysis
Assay data:2 Tested
Inhibition of LSD2 (unknown origin) (26 to 822 residues) expressed in baculovirus-infected Sf9 insect cells using K4-dimethylated H3 as substrate by peroxidase-coupled method
Assay data:3 Active, 43 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to KDM1B (unknown origin) assessed as inhibition constant using Lys4-dimethylated H3 peptide as substrate incubated for 30 mins by enzymatic assay
Inhibition of human LSD2 using Bio-H3K4me2 (1 to 24 residues) as substrate incubated for 1 hr by TR-FRET assay
Assay data:2 Active, 2 Tested
Inhibition of LSD2 (unknown origin) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled assay
Assay data:3 Tested
Inhibition of recombinant mouse LSD2 expressed in Escherichia coli using histone H3 peptide dimethylated at Lys4 as substrate by peroxidase-coupled assay
Inhibition of LSD2 (unknown origin) at
Inhibition of human full length LSD2 using biotin-labeled H3K4me2 (1 to 24 residues) as substrate after 1 hr by TR-FRET assay
Assay data:3 Active, 18 Tested
Inhibition of KDM1B (unknown origin)
Assay data:4 Tested
Assay data:6 Tested
Assay data:3 Active, 14 Tested
Inhibition of LSD2 in human HeLa cells assessed as H3K4me1/H3 ratio at 10 uM after 24 hrs by Western blot analysis in absence of fetal bovine serum (Rvb = 1 No_unit)
Inhibition of LSD2 in human HeLa cells assessed as H3K4me1/H3 ratio at 5 uM after 24 hrs by Western blot analysis in absence of fetal bovine serum (Rvb = 1 No_unit)
Inhibition of full length N-terminal His-tagged human LSD2 (1 to 822 residues) expressed in Escherichia coli BL21(DE3) cells using H3K4me2 peptide substrate by MALDI-TOF mass spectrometric analysis
Assay data:1 Active, 8 Tested
Inhibition of LSD2 in human HeLa cells assessed as H3K4me1/H3 ratio at 20 uM after 24 hrs by Western blot analysis in absence of fetal bovine serum (Rvb = 1 No_unit)
Inhibition of recombinant human LSD2 using H3K4 peptide as substrate assessed as decrease in H3K4 demethylation after 1 hr by mass spectroscopic analysis
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