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Agonist activity at NPRC in human Hela cells assessed as decrease in forskolin-induced cAMP level at 100 uM in presence of osteocrin
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at NPRC in human Hela cells assessed as decrease in forskolin-induced cAMP level at 100 uM in presence of M372049
Agonist activity at NPRC in human Hela cells assessed as decrease in forskolin-induced cAMP level at 100 uM relative to control
Binding affinity to CM5 sensor chip immobilized human NPR-C (27 to 541 residues) assessed as maximum response by surface plasmon resonance analysis relative to control
Binding affinity to CM5 sensor chip immobilized human NPR-C (27 to 541 residues) assessed as dissociation constant by surface plasmon resonance analysis
Assay data:22 Tested
Agonist activity at NPRC in human HeLa cells assessed as decrease in forskolin-induced cAMP level at 100 nM in presence of M372049
Assay data:1 Tested
Agonist activity at NPRC in human HeLa cells assessed as decrease in forskolin-induced cAMP level at 100 nM in presence of osteocrin
Agonist activity at NPRC in human HeLa cells assessed as decrease in forskolin-induced cAMP level at 100 nM
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at NPRC in knock out mouse mesenteric arteries assessed as vasorelaxation by Organ bath assay
Assay data:2 Active, 3 Tested
Agonist activity at NPRC in wild type mouse mesenteric arteries assessed as vasorelaxation by Organ bath assay
Assay data:3 Active, 3 Tested
Displacement of Flu-P19 probe from human NPR-C (27 to 541 residues) at 300 uM by fluorescence polarization analysis relative to control
Displacement of Flu-P19 probe from human NPR-C (27 to 541 residues) by fluorescence polarization analysis
Assay data:5 Tested
Vasoreactivity in Rat Mesenteric Arteries In Vitro from US Patent US10087144: "Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 H)-quinolone"
Assay data:4 Active, 1 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Atrial Natriuretic Factor (ANF) Eurofins-Panlabs radioligand binding assay
SummaryRelated BioAssays by Target
Displacement of [125I]-human ANP from His-tagged and Fc fragment containing human NPR-3 extracellular domain expressed in FreeStyle 293 cells incubated for 2 hrs by top count method
Assay data:26 Active, 16 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activity at NPR-3 in C57BL/6J mouse primary adipocytes assessed as increase in mANP-stimulated cGMP production at 1 uM pre-incubated for 30 mins before mANP stimulation for 15 mins by enzyme immunoassay
Inhibition of ANP receptor at 1 uM
Binding affinity for non-vasorelaxant receptor by competitive displacement of [125I]-AP(103-126) from rabbit lung membranes
Assay data:2 Tested
Apparent binding constant against multiple binding sites
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding relative potency towards non-vasorelaxant binding site against AP(103-126); Not tested
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