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Displacement of 125I-liraglutide from GLP-1 (unknown origin) by competitive binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human N-terminal GLP-1 receptor
Agonist activity at mouse GLP-1R expressed in CHO cells assessed as increase in cAMP accumulation relative to GLP-1
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at mouse GLP-1R expressed in CHO cells assessed as increase in cAMP accumulation
Assay data:11 Active, 5 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
The Alizarin Assay (ARS) (Lactate) from US Patent US11767332: "Glucose-sensitive albumin-binding derivatives"
Assay data:36 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
The Alizarin Assay (ARS) (Glucose) from US Patent US11767332: "Glucose-sensitive albumin-binding derivatives"
Assay data:43 Tested
Tag-Lite Binding Assay from US Patent US20230271949: "GLP-1R MODULATING COMPOUNDS"
Assay data:53 Active, 46 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Agonist activity at human GLP-1R expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assay relative to control
Assay data:18 Tested
Agonist activity at human GLP-1R expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assay
Assay data:18 Active, 17 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Concentration: 0.0000004
Assay data:211 Tested
SummaryRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Concentration: 0.000002
GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Concentration: 0.00001
Assay data:437 Tested
Agonist activity at FAP-tagged human GLP-1R expressed in HEK293 cells assessed as receptor internalization measured after 30 mins by nuclear staining based confocal microscopic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at FAP-tagged human GLP-1R expressed in HEK293 cells assessed as receptor internalization preincubated for 30 mins followed by compound washout and measured after 2 hrs by nuclear staining based confocal microscopic analysis
Assay data:1 Tested
Activation of mouse GLP-1R expressed in CHO cells assessed as increase in cAMP accumulation
Activation of rat GLP-1R expressed in CHO cells assessed as increase in cAMP accumulation
Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assay
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Agonist activity at FAP-tagged human GLP-1R expressed in HEK293 cells assessed as receptor internalization by measuring maximal efficacy relative to control
Assay data:3 Tested
Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cell assessed as induction of beta-arrestin 2 recruitment by measuring maximum efficacy incubated for 90 mins by pathHunter assay relative to control
Assay data:4 Tested
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