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Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate at 12.5 to 200 uM preincubated for 10 mins followed by substrate addition and measured for 50 mins by microplate reader assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CMS sensor chip immobilized MMP-14 catalytic domain (unknown origin) assessed as equilibrium dissociation constant by surface plasmon resonance analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measured for 50 mins by microplate reader assay
Assay data:3 Tested
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate at 47.6 uM preincubated for 10 mins followed by substrate addition by primary HTS analysis relative to control
Assay data:1 Active, 3 Tested
Inhibition of MMP14 (unknown origin)
Inhibition of MMP14 (unknown origin) assessed as inhibition constant
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MMP14 (unknown origin) by FRET assay
Inhibition of MMP-14 (unknown origin) at 20 uM by fluorometric assay
Inhibition of MMP-14 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins by fluorescence based analysis
Assay data:4 Tested
Inhibition of MMP-14 (unknown origin) using fTHP-15(FAM) as substrate at 10 uM
Assay data:9 Tested
Inhibition of MMP-14 (unknown origin) using fTHP-15(FAM) as substrate at 5 uM
Assay data:5 Tested
Selectivity interaction (MMPs panel (FRET assay)) EUB0000730a MMP14
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP14
SummaryRelated BioAssays by Target
Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP14
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP14
Inhibition of recombinant human MMP14 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of human MMP-14 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent analysis
Inhibition of human MMP-14 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by susbstrate addition by photon-counter spectrophotometer analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of MMP-14 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assay
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