Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19635671.

Activity Inhibition Assay on CDK Family Kinases from US Patent US20240109898: "SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF"

Source:: BindingDB

Protein Targets:: Cyclin-A2; ...
Total:: 6

Assay data:84 Active, 83 Activity ≤ 1 µM, 84 Tested

AID:: 1963567

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19635242.

CDK2/Cyclin E1 Full Length ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"

Source:: BindingDB

Protein Targets:: Cyclin-dependent kinase 2; ...
Total:: 2

Assay data:111 Active, 104 Activity ≤ 1 µM, 122 Tested

AID:: 1963524

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19635233.

CDK1/Cyclin B1 ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"

Source:: BindingDB

Protein Targets:: Cyclin-dependent kinase 1; ...
Total:: 2

Assay data:83 Active, 59 Activity ≤ 1 µM, 122 Tested

AID:: 1963523

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19634964.

PI3K-delta Scintillation Proximity Assay from US Patent US11926616: "Aminopyrazine diol compounds as PI3K-γ inhibitors"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; ...
Total:: 1

Assay data:46 Active, 43 Activity ≤ 1 µM, 46 Tested

AID:: 1963496

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19634955.

PI3K-gamma Scintillation Proximity Assay from US Patent US11926616: "Aminopyrazine diol compounds as PI3K-γ inhibitors"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform ; ...
Total:: 1

Assay data:46 Active, 46 Activity ≤ 1 µM, 46 Tested

AID:: 1963495

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19634906.

CDK2/Cyclin E1 HTRF Enzyme Activity Assay from US Patent US11919904: "Sulfonylamide compounds as CDK2 inhibitors"

Source:: BindingDB

Protein Targets:: Cyclin-dependent kinase 2; ...
Total:: 2

Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested

AID:: 1963490

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19633447.

CDK2/Cyclin E1 Full length ADP-Glo Kinase Assay from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"

Source:: BindingDB

Protein Targets:: Cyclin-dependent kinase 2; ...
Total:: 2

Assay data:95 Active, 92 Activity ≤ 1 µM, 97 Tested

AID:: 1963344

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19633438.

CDK1/Cyclin B1 ADP-Glo Kinase Assay from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"

Source:: BindingDB

Protein Targets:: Cyclin-dependent kinase 1; ...
Total:: 2

Assay data:75 Active, 1 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 99 Tested

AID:: 1963343

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19633369.

Assay for Inhibition of CDK2/CyclinE1 from US Patent US20240033264: "CDK INHIBITORS"

Source:: BindingDB

Protein Targets:: Cyclin-dependent kinase 2; ...
Total:: 2

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1963336

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 196326710.

Cross screening panel

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Tested

AID:: 1963267

Summary Related BioAssays by Target

Select item 196321811.

Cross screening panel

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Tested

AID:: 1963218

Summary Related BioAssays by Target

Select item 196317012.

Cross screening panel

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Tested

AID:: 1963170

Summary Related BioAssays by Target

Select item 196307313.

Safety47 Scan (DiscoverX - Eurofins)

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:1 Tested

AID:: 1963073

Summary Related BioAssays by Target

Select item 196297614.

CSNK1E SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Casein kinase I isoform epsilon

Assay data:1 Tested

AID:: 1962976

Summary Related BioAssays by Target

Select item 196294715.

PIM1 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase pim-1

Assay data:1 Tested

AID:: 1962947

Summary Related BioAssays by Target

Select item 196293716.

PIM3 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase pim-3

Assay data:1 Tested

AID:: 1962937

Summary Related BioAssays by Target

Select item 196293117.

MAPK14 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 14

Assay data:1 Tested

AID:: 1962931

Summary Related BioAssays by Target

Select item 196293018.

MAPK13 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 13

Assay data:1 Tested

AID:: 1962930

Summary Related BioAssays by Target

Select item 196292419.

GSK3B SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Glycogen synthase kinase-3 beta

Assay data:1 Tested

AID:: 1962924

Summary Related BioAssays by Target

Select item 196289220.

CDK2 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Cyclin-dependent kinase 2

Assay data:1 Tested

AID:: 1962892

Summary Related BioAssays by Target

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Target

Proteins (93)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (1)
BioAssays with compounds reported as validated chemical probes

Active Compounds (7,283)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (887)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (5,836)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (4)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (7,746)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (7)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (48)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (15,328)
BioAssays extracted from the literature
NIH MLP (52)
BioAssays deposited by the NIH Molecular Libraries Program
Other (3,913)
BioAssays deposited by other experimentalists

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