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Inhibition of OCT2(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT2 using ASP+ as substrate incubated for 5 mins
Assay data:12 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of OCT1(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT1 using ASP+ as substrate incubated for 5 mins
Assay data:1 Active, 12 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of OCT1(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT1 using ASP+ as substrate at 50 uM incubated for 5 mins by fluorescence based microplate reader analysis relative to control
Assay data:10 Tested
Substrate activity at OCT2 (unknown origin)
Assay data:1 Tested
Substrate activity at OCT1 (unknown origin)
Inhibition of OCT2 (unknown origin)
Inhibition of OCT1 (unknown origin)
OCT2 Inhibition Assay from US Patent US11548901: "Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections"
Assay data:19 Active, 11 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9732092: "Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]OXAZEPINES and methods for treating viral infections"
Inhibition Assay from US Patent US9663528: "Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections"
Assay data:18 Active, 10 Activity ≤ 1 µM, 22 Tested
Inhibition of OCT2 (unknown origin) at upto 3 uM
Inhibition of OCT1 (unknown origin) at 1 to 10 uM
Inhibition of OCT2 (unknown origin) at 1 to 10 uM
Inhibition of human SLC22A2 expressed in HEK293 cells in presence of para-aminohippuric acid/metformin
Substrate activity at OCT2 (unknown origin) at 10 uM
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