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Inhibition of ALK6 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ALK3 (unknown origin)
Inhibition of BMPR1A (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human GST tagged ALK3 incubated for 30 mins in presence of ATP by QSSA Kit method
Inhibition of ALK4 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ALK4 (unknown origin) at 1 uM relative to control
No assay from US Patent US11759530: "TKI permeability enhancers"
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases from US Patent US11702401: "Compounds and methods of use"
Assay data:33 Active, 32 Activity ≤ 1 µM, 36 Tested
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity from US Patent US11654147: "ALK2 inhibitors and methods for inhibiting BMP signaling"
Assay data:149 Active, 1 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 170 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a BMPR1B
SummaryRelated BioAssays by Target
Affinity Biochemical interaction (Radioactive kinase assay (ACVR1B)) EUB0000312b ACVR1B
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000710a ACVR1B
Affinity On-target Cellular interaction (Reporter gene assay) EUB0000312b ACVR1B
Affinity Phenotypic Cellular interaction (Western blot (inhibition of SMAD2/3 phosphorylation)) EUB0000710a ACVR1B
Affinity Phenotypic Cellular interaction (Western blot (inhibition of SMAD2/3 phosphorylation)) EUB0000312b ACVR1B
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human wild type partial length BMPR1A (Q214 to I532 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM relative to control
Assay data:23 Active, 13 Activity ≤ 1 µM, 28 Tested
Inhibition of human recombinant ALK3 (198 to 525 residues) expressed in baculovirus-infected insect cells by ADP-Glo kinase assay
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