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GTP-KRAS and cRAF Interaction Assay from US Patent US20240199644: "Fused Ring Derivatives Useful as KRAS G12D Inhibitors"
Assay data:16 Active, 4 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Surface Plasmon Resonance Assay from US Patent US20240197735: "METHODS AND COMPOSITIONS COMPRISING A BRAF INHIBITOR AND A PD-1 BINDING ANTAGONIST"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Kinase Assay from US Patent US20240174621: "METHYLQUINAZOLINONE DERIVATIVES"
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) from US Patent US20240150366: "4-AMINOQUINAZOLINE COMPOUND"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
RAF1 Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of c-RAF (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RAF1 (unknown origin) at 10 uM using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based hotspot kinase assay relative to control
Assay data:4 Tested
Inhibition of RAF1 (unknown origin) using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based hotspot kinase assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of cRAF1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant GST-fused cRAF expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of KRAS (unknown origin) to CRAF (unknown origin) protein protein interaction
Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of RAF1 (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human partial length wild type c-RAF (I330/T640) expressed in bacterial system at 1 uM by KINOMEscan analysis relative to control
Stabilization of 14-3-3 eta (unknown origin)/ c-Raf (unknown origin)
Inhibition of c-Raf (unknown origin)
Assay data:3 Tested
Inhibition of human CRAF incubated for 40 mins by scintillation counter analysis
The stabilization effect of I-2 and avutometinib (VS6766) on MEK1-CRAF complex were tested and compared using SPR. from US Patent US20230382863: "MEK INHIBITORS AND USES THEREOF"
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
AlphaLISA Assay from US Patent US20230382863: "MEK INHIBITORS AND USES THEREOF"
Assay data:9 Active, 9 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
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