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Biochemical AlphaScreen assay from US Patent US11905273: "Inhibitors for the B-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction"
Assay data:4 Active, 5 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of beta catenin/Tcf4 (unknown origin) protein protein interaction
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of beta-catenin phosphorylation in human HT-29 cells at 4 uM incubated for 72 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of beta-catenin phosphorylation in human HT-29 cells at 2 uM incubated for 72 hrs by Western blot analysis
Inhibition of beta-catenin phosphorylation in human HT-29 cells at 1 uM incubated for 72 hrs by Western blot analysis
Inhibition of beta catenin/Tcf4 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of N-terminal beta-catenin/full length myc-tagged TCF (unknown origin) trasfected in HEK293 cells measured for 48 hrs by
Binding affinity to beta-catenin/Tcf (unknown origin) assessed as gibbs free energy change
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of beta-catenin/E-cadherin protein-protein interaction in human HCT-116 cells at 1 to 12.5 uM incubated for 24 hr by Co-immunoprecipitation assay
Inhibition of beta-catenin/BCL9 protein-protein interaction in human HCT-116 cells at 1 to 12.5 uM incubated for 24 hr by Co-immunoprecipitation assay
Inhibition of full length beta-catenin (1 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction assessed as inhibition constant incubated for 2 hr by Alphascreen assay
Inhibition of full length beta-catenin (1 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction incubated for 2 hr by fluorescence anisotropy binding assay
Inhibition of full length beta-catenin (1 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction incubated for 2 hr by Alphascreen assay
Inhibition of full length wild type beta-catenin/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction in human SW480 cells at 1 to 10 uM incubated for 3 hr by immunoblot based pull-down assay
Inhibition of full length beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction assessed as inhibition constant incubated for 1 hr by Alphascreen assay
Assay data:14 Active, 1 Activity ≤ 1 µM, 43 Tested
Inhibition of full length beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay
Assay data:12 Active, 43 Tested
Binding affinity to beta catenin (unknown origin) to BCL assessed as inhibition constant by alpha screening assay
Binding affinity to human beta catenin double mutant assessed as dissociation constant by alpha assay
Binding affinity to human beta catenin assessed as dissociation constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of beta-catenin/Tcf4 (unknown origin) in human SW480 cells assessed as reduction in cyclin D1 level qRT-PCR analysis
Assay data:2 Active, 2 Tested
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