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Inhibition of human IBAT
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to ASBT (unknown origin) assessed as inhibition constant
Assay data:2 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Pharmaceutical Effect Mean Inhibitory Effect from US Patent US10487111: "IBAT inhibitors for the treatment of liver diseases"
Assay data:12 Active, 11 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9040518: "Chemical compounds"
Assay data:69 Active, 1 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 70 Tested
Pharmaceutical Effect Mean Inhibitory Effect from US Patent US10093697: "IBAT inhibitors for the treatment of liver diseases"
Assay data:11 Active, 10 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of human ASBT-mediated [3H]-TCA uptake expressed in human HepG2 cells at 2 uM
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human ASBT
Assay data:1 Tested
Inhibition of ASBT (unknown origin) at 1 to 10 uM
Inhibition of mouse IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptake
Assay data:3 Tested
Inhibition of human IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptake
Inhibition of human IBAT expressed in CHO cells assessed as reduction in [3H]taurocholic acid uptake incubated for 30 to 60 mins by scintillation counting method
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as MDC positive cells at 20 uM after 24 hrs by transmission electron microscopy (Rvb = 0.60%)
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as MDC positive cells at 20 uM after 12 hrs by transmission electron microscopy (Rvb = 0.60%)
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as increase in Beclin- 1 level after 9 days by Western blot analysis
Assay data:1 Active, 1 Tested
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as decrease in p62 level at 20 uM after 24 hrs by Western blot analysis
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as increase in LC3-2 level at 20 uM after 24 hrs by Western blot analysis
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as GFP-LC3 localization at 20 uM by transmission electron microscopy
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as GFP-LC3 localization at 20 uM after 24 hrs by transmission electron microscopy
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as appearance of autophagosome and extensive cytoplasm vacuolization at 20 uM after 24 hrs by transmission electron microscopy
Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis
Assay data:43 Active, 39 Activity ≤ 1 µM, 49 Tested
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