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Inhibition of NKCC1 in human HT-29 cells assessed as inhibition of rubidium uptake incubated for 20 min by atomic absorption spectroscopy
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Thallium based assay for SLC12A2 using HEK-293 SLC12A2 OE cells
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of NKCC1 (unknown origin) transfected in HEK293 cells expressing mbYFPQS plasmid assessed as reduction in Cl- influx at 100 uM incubated for 30 mins by fluorescence multiplate reader analysis
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of NKCC1 (unknown origin) transfected in HEK293 cells expressing mbYFPQS plasmid assessed as reduction in Cl- influx at 10 uM incubated for 30 mins by fluorescence multiplate reader analysis
Assay data:22 Tested
Inhibition of NKCC1 (unknown origin) transfected in HEK293 cells expressing mbYFPQS plasmid assessed as reduction in Cl- influx at 100 uM incubated for 30 mins by fluorescence multiplate reader analysis relative to control
Assay data:26 Tested
Inhibition of NKCC1 (unknown origin) transfected in HEK293 cells expressing mbYFPQS plasmid assessed as reduction in Cl- influx at 10 uM incubated for 30 mins by fluorescence multiplate reader analysis relative to control
Assay data:10 Tested
Inhibition of human NKCC1 expressed in COS7 co-expressing EYFP-HIF assessed as effect on I(-) gradient at 25 uM by YFP-based fluorescence quenching assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of NKCC1 in human bronchial epithelial cells assessed as effect on short-circuit current at 25 uM pre-incubated for 30 mins
Inhibition of NKCC1 in human primary bronchial epithelial cells assessed as effect on short-circuit current at 10 uM after 10 mins by voltage clamp method
Assay data:2 Tested
Human Kidney-specific Na-K-Cl symporter (SLC12 family of cation-coupled chloride transporters)
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human Basolateral Na-K-Cl symporter (SLC12 family of cation-coupled chloride transporters)
Antagonist activity at NKKC1 expressed in human HEK293 cells assessed as [86Rb] uptake after 30 mins by scintillation counting
Antagonist activity at NKKC1 expressed in human HEK293 cells assessed as [86Rb] uptake at 50 uM after 30 mins by scintillation counting
Antagonist activity at NKKC1 expressed in human HEK293 cells assessed as [86Rb] uptake up to 100 uM after 30 mins by scintillation counting
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Rubidium Flux
Assay data:22 Active, 3 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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