Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19617451.

Compound was evaluated for inhibition of human ERBB2 in an in vitro cell free assay measured by Caliper microfluidic capillary electrophoresis, time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:6 Active, 5 Activity ≤ 1 µM, 83 Tested

AID:: 1961745

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19559442.

Inhibition of HER2 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Tested

AID:: 1955944

Summary PubMed Citation Related BioAssays by Target

Select item 19513033.

Inhibition of HER2 (unknown origin) at 500 nM relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Tested

AID:: 1951303

Summary PubMed Citation Related BioAssays by Target

Select item 19512904.

Inhibition of HER2 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1951290

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19498335.

Inhibition of human recombinant ERBB2 expressed in Escherichia coli

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Tested

AID:: 1949833

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19489266.

Inhibition of ERBB2 (unknown origin) autophosphorylation expressed in human BT-474 cells by ELISA-based assay

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:2 Activity ≤ 1 µM, 2 Tested

AID:: 1948926

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19465217.

Binding affinity to ERRB2 (unknown origin) assessed as strong interaction at 100 nM

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Tested

AID:: 1946521

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19402648.

Inhibition of c-ErbB-2 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:4 Tested

AID:: 1940264

Summary PubMed Citation Related BioAssays by Target

Select item 19399769.

Inhibition of HER2 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939976

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193546510.

Inhibition of human HER2 at 1 uM by hotspot assay relative to control

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Tested

AID:: 1935465

Summary PubMed Citation Related BioAssays by Target

Select item 193003811.

Inhibition of recombinant HER2 (676 to 1255 residues) (unknown origin) expressed in baculovirus infected sf9 cells autophosphorylation incubated for 1 hrs in presence of ATP by time-resolved fluorometry

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1930038

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192876712.

Binding affinity to HER2 in human BT474 cells assessed as dissociation constant by measuring low affinity ligand binding site by LigandTracer technique

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1928767

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192876613.

Binding affinity to HER2 in human BT-474 cells assessed as dissociation constant by measuring high affinity ligand binding site by LigandTracer technique

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1928766

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192769414.

Inhibition of HER2 (unknown origin) incubated for 1 hrs in presence of ATP by ELISA assay

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:2 Active, 2 Tested

AID:: 1927694

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192766315.

Inhibition of human HER2

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1927663

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192765216.

Inhibition of HER2 (unknown origin) incubated for 1 hrs by ELISA assay

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:2 Active, 2 Tested

AID:: 1927652

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192764817.

Inhibition of human HER2 incubated for 1 hrs in presence of ATP by ELISA assay

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1927648

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192531318.

Binding affinity to HER2 (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1925313

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192419219.

Inhibition of human ErbB2

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1924192

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192307720.

Inhibition of HER2 (unknown origin)

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Tested

AID:: 1923077

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (5)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (488)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (46)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (376)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (519)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (970)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (37)
BioAssays deposited by other experimentalists

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