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Time dependent inhibition of CYP450 (unknown origin) at 10 uM
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CYP450 (unknown origin) at 10 uM
Inhibition of CYP450 (unknown origin)
Induction of CYP450 in human assessed as reduction in tacrolimus AUC
Induction of CYP450 in human assessed as reduction in indinavir AUC
Induction of human CYP450 assessed as decrease in darunavir AUC
Assay data:2 Tested
Induction of CYP450 (unknown origin) assessed as decrease in 17alpha-ethinyl estradiol AUC
Induction of CYP450 in human assessed as reduction in amprenavir AUC
Induction of CYP450 in human assessed as reduction in nifedipine AUC
Induction of CYP450 in human assessed as reduction in midazolam AUC
Assay data:12 Tested
Induction of CYP450 in human assessed as reduction in Ivacaftor AUC
Induction of CYP450 in human assessed as reduction in rosiglitazone AUC at 600 mg, QD
Induction of CYP450 in human assessed as reduction in bupropion AUC at 200 mg, QD
Inhibition of CYP450 in human liver microsomes
Inhibition of recombinant human CYP1B1 using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assay
Assay data:59 Active, 2 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 60 Tested
Inhibition of recombinant human CYP1B1 assessed as inhibition ratio at 100 nM using 7-ethyl-0-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assay relative to control
Assay data:38 Tested
Inhibition of human CYP1B1
Assay data:1 Active, 1 Tested
Inhibition of CYP1B1 (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryPubMed CitationRelated BioAssays by Target
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