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HTRF (BCL2A1)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of N-terminal GST-tagged human recombinant Mcl-1 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay
Assay data:26 Active, 17 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of his-tagged human recombinant Bcl-2 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay
Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested
Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant BFL-1 (unknown origin) by fluorescence polarization-based competitive binding assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of fluorescent-labeled BID-BH3 peptide from His-tagged BFL-1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assay
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of Bfl-1/Bim (unknown origin) incubated for 30 mins by TR-FRET assay
Assay data:2 Active, 2 Tested
Inhibition of Bfl-1/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of Bfl-1/Bim (unknown origin) by fluorescence polarization assay
Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by TR-FRET assay
Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by fluorescence polarization assay
Inhibition of BH3 peptide binding to Bfl-1 (unknown origin)
AlphaLISA Assay from US Patent US11667652: "MCL1 inhibitors"
Assay data:204 Active, 193 Activity ≤ 1 nM, 204 Activity ≤ 1 µM, 204 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
AlphaLISA assay from US Patent US11643400: "MCL-1 inhibitors"
Assay data:443 Active, 402 Activity ≤ 1 nM, 443 Activity ≤ 1 µM, 443 Tested
Inhibition of human BFL-1/PUMA protein-protein interaction in human Kasumi 1 cells assessed as decrease in PUMA protein level at 80 uM measured after 5 hrs by co-immunoprecipitation assay
Inhibition of human BFL-1/PUMA protein-protein interaction in human Kasumi 1 cells assessed as increase in BFL-1 protein level at 20 to 80 uM measured after 5 hrs by co-immunoprecipitation assay
Binding affinity to His-tagged recombinant BFL-1 (1 to 151 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by surface plasmon resonance analysis
Binding affinity to His-tagged recombinant BFL-1 (1 to 151 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as association constant by surface plasmon resonance analysis
SummaryPubMed CitationRelated BioAssays by Target
Displacement of fluorescein tagged BID BH3 peptide from His-tagged recombinant BFL-1 (1 to 151 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant incubated for 24 hrs by fluorescence polarization-based competitive binding assay
Assay data:8 Active, 2 Activity ≤ 1 µM, 19 Tested
Inhibition of His-tagged human BFL-1(1 to 151 residues) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization-based binding assay
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