Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19630731.

Safety47 Scan (DiscoverX - Eurofins)

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:1 Tested

AID:: 1963073

Summary Related BioAssays by Target

Select item 19624452.

ROCK2 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Tested

AID:: 1962445

Summary Related BioAssays by Target

Select item 19622983.

ROCK2 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Tested

AID:: 1962298

Summary Related BioAssays by Target

Select item 19608774.

Inhibition of ROCK1 (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:1 Tested

AID:: 1960877

Summary PubMed Citation Related BioAssays by Target

Select item 19558245.

Inhibition of ROCK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:20 Active, 1 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested

AID:: 1955824

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19558236.

Inhibition of ROCK1 (unknown origin)

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:14 Active, 12 Activity ≤ 1 µM, 20 Tested

AID:: 1955823

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19531867.

Inhibition of ROCK1 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953186

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19531848.

Inhibition of ROCK2 (unknown origin) using S6-peptide as substrate in presence of [33P]-ATP by HTRF assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1953184

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19531839.

Inhibition of ROCK1 (unknown origin) using KKRPQRRYSNVF as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in presence of ATP by Z'-LYTE fluorescence plate reader assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1953183

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195318210.

Inhibition of ROCK2 (unknown origin) using KKRPQRRYSNVF as substrate preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in presence of ATP by Z'-LYTE fluorescence plate reader assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1953182

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195318011.

Inhibition of ROCK2 in rat A7R5 cells assessed as MLC phosphorylation at T18/S19 by ELISA

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953180

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195317912.

Inhibition of ROCK2 (unknown origin) using 33P-ATP as substrate and measured after 120 mins by radiometric analysis

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953179

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195317813.

Inhibition of ROCK2 (unknown origin) incubated for 1 hr by KTNOMEscan kinase assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953178

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195317714.

Inhibition of ROCK1 (unknown origin) incubated for 1 hr by KTNOMEscan kinase assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953177

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195317615.

Inhibition of GST-tagged ROCK2 (5 to 554 residues) (unknown origin) using S6-peptide as substrate preincubated for 15 mins followed by 33P-ATP addition and measured after 120 mins by scintillation counter analysis

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1953176

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195317516.

Inhibition of GST-tagged ROCK1 (1 to 535 residues) (unknown origin) using S6-peptide as substrate preincubated for 15 mins followed by 33P-ATP addition and measured after 120 mins by scintillation counter analysis

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1953175

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195317417.

Inhibition of human recombinant ROCK2 assessed as inhibition constant by microfluidic mobility shift method

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953174

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195317218.

Inhibition of ROCK2 (unknown origin) using STK2 as substrate incubated for 4 hrs by HTRF assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:12 Active, 4 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested

AID:: 1953172

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195316719.

Inhibition of human ROCK1

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1953167

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195316620.

Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate in presence of ATP by microplate reader analysis

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1953166

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (8)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (441)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (91)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (387)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (494)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (1,028)
BioAssays extracted from the literature
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BioAssays deposited by the NIH Molecular Libraries Program
Other (95)
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