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Inhibition of ALK6 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ALK3 (unknown origin)
Inhibition of BMPR1A (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human GST tagged ALK3 incubated for 30 mins in presence of ATP by QSSA Kit method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases from US Patent US11702401: "Compounds and methods of use"
Assay data:33 Active, 32 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity from US Patent US11654147: "ALK2 inhibitors and methods for inhibiting BMP signaling"
Assay data:149 Active, 1 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 170 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a BMPR1B
SummaryRelated BioAssays by Target
Inhibition of human wild type partial length BMPR1A (Q214 to I532 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM relative to control
Assay data:23 Active, 13 Activity ≤ 1 µM, 28 Tested
Inhibition of human recombinant ALK3 (198 to 525 residues) expressed in baculovirus-infected insect cells by ADP-Glo kinase assay
Inhibition of GST-tagged human recombinant ALK3 expressed in insect cells using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis
Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation activity using peptide substrate in presence of ATP and measured after 1 hrs by HTRF assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Binding affinity to wild type ALK3 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
Binding affinity to wild type ALK6 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
Inhibition of wild type ALK6 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of wild type ALK3 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assay
BMPR1B DiscoveRx kinase panel
BMPR1A DiscoveRx kinase panel
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