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DYRK2 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of DYRK3 (unknown origin) at 10 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of DYRK2 (unknown origin) at 10 uM relative to control
Inhibition of DYRK2 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:28 Active, 13 Activity ≤ 1 µM, 56 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:37 Active, 20 Activity ≤ 1 µM, 56 Tested
Inhibition of DYRK2 in human 22Rv1 cells assessed as reduction in 4E-BP1 phosphorylation at 2 to 8 uM incubated for 24 hrs by Western blot analysis
Inhibition of DYRK2 in human DU-145 cells assessed as reduction in 4E-BP1 phosphorylation at 2 to 8 uM incubated for 24 hrs by Western blot analysis
Inhibition of hexa His-tagged DYRK2 (72 to 479 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as substrate phosphorylation using 4E-BP1 as substrate in presence of [gamma33-P]ATP incubated for 2 hrs by scintillation counter analysis
Assay data:26 Active, 1 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 30 Tested
Inhibition of human GST-tagged DYRK2 expressed in Escherichia coli BL21 (DE3) using woodtide as substrate in presence of [gamma33-P]ATP incubated for 30 mins by Scintillation counter analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of DYRK3 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human DYRK2
DYRK2 Kinase Activity Analysis and Detection Method from US Patent US20230303553: "CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000009b DYRK2
Selectivity interaction (KinomeScan (Invitrogen)) EUB0000642a DYRK3
Selectivity interaction (Enzymatic assay (Invitrogen)) EUB0000642a DYRK3
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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