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CDK4/Cyclin D1 CHEF Assay from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:79 Active, 76 Activity ≤ 1 µM, 81 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
CDK6/Cyclin D3 ADP-Glo Kinase Assay from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:90 Active, 82 Activity ≤ 1 µM, 97 Tested
CDK4/Cyclin D1 Mobility Shift Assay (MSA) from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:18 Active, 16 Activity ≤ 1 µM, 18 Tested
Assay for Inhibition of CDK6/CyclinD3 from US Patent US20240033264: "CDK INHIBITORS"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Assay for Inhibition of CDK4/CyclinD1 from US Patent US20240033264: "CDK INHIBITORS"
Inhibition of full length human CDK4/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate at 10 uM incubated for 60 mins in presence of ATP relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full length human CDK6/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate at 10 uM incubated for 60 mins in presence of ATP relative to control
Inhibition of full length human CDK6/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate incubated for 60 mins in presence of ATP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of full length human CDK4/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate incubated for 60 mins in presence of ATP
Inhibition of CDK6/Cyclin D3 (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of CDK4/Cyclin D1 (unknown origin)
Covalent inhibition of CDK6 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based kinase assay
Covalent inhibition of CDK4 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based kinase assay
Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as inhibition of CDK4 expression level at 1 to 8 uM incubated for 24 hrs by western blot assay
Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as inhibition of CDK6 expression level at 1 to 8 uM incubated for 24 hrs by western blot assay
Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as reduction of RB phosphorylation at Ser780 residue level at 1 to 8 uM incubated for 24 hrs by western blot assay
Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as inhibition of CDK4 expression level at 8 uM incubated for 24 hrs by western blot assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as inhibition of CDK6 expression level at 8 uM incubated for 24 hrs by western blot assay
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