Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19633661.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay from US Patent US20240043404: "APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES"

Source:: BindingDB

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 1

Assay data:372 Active, 356 Activity ≤ 1 nM, 372 Activity ≤ 1 µM, 372 Tested

AID:: 1963366

Summary Related BioAssays by Target

Select item 19629912.

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Tested

AID:: 1962991

Summary Related BioAssays by Target

Select item 19571623.

Inhibition of N-terminal GST-tagged human recombinant Mcl-1 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:26 Active, 17 Activity ≤ 1 µM, 29 Tested

AID:: 1957162

Summary Related BioAssays by Target

Select item 19571584.

Inhibition of his-tagged human recombinant Bcl-2 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay

Source:: ChEMBL

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 2

Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested

AID:: 1957158

Summary Related BioAssays by Target

Select item 19564375.

Inhibition of BCL-2 (unknown origin) using FITC-Ahx-GQVGRQLAIIGDDINR-CONH2 as substrate incubated for 4 hrs by fluorescence polarization competition assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1956437

Summary Related BioAssays by Target

Select item 19392106.

Inhibition of fluorescent-labeled BID-BH3 peptide binding to Bcl-2 (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939210

Summary Related BioAssays by Target

Select item 19383477.

Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1938347

Summary Related BioAssays by Target

Select item 19383438.

Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant Bcl-2 (unknown origin) by fluorescence polarization-based competitive binding assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Tested

AID:: 1938343

Summary Related BioAssays by Target

Select item 19383399.

Inhibition of Bcl-2 (unknown origin)

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1938339

Summary Related BioAssays by Target

Select item 193833410.

Inhibition of Bfl-1/Bim (unknown origin) incubated for 30 mins by TR-FRET assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 2 Tested

AID:: 1938334

Summary Related BioAssays by Target

Select item 193833311.

Inhibition of Bfl-1/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1938333

Summary Related BioAssays by Target

Select item 193833212.

Inhibition of Bfl-1/Bim (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1938332

Summary Related BioAssays by Target

Select item 193166513.

Inhibition of Bcl-2 (unknown origin) by ELISA analysis

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Tested

AID:: 1931665

Summary Related BioAssays by Target

Select item 193166314.

Binding affinity to recombinant Bcl-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by MST analysis

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Tested

AID:: 1931663

Summary Related BioAssays by Target

Select item 193166215.

Binding affinity to Bcl-2 (unknown origin) by ELISA analysis

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Tested

AID:: 1931662

Summary Related BioAssays by Target

Select item 193165516.

Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by TR-FRET assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1931655

Summary Related BioAssays by Target

Select item 193165117.

Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by competitive fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1931651

Summary Related BioAssays by Target

Select item 193164918.

Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1931649

Summary Related BioAssays by Target

Select item 193164719.

Inhibition of Flu-BakBH3 binding to GST-tagged Bcl-2 (unknown origin) preincubated for 10 mins followed by Flu-BakBH3 addition and measured after 30 mins by competitive fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Tested

AID:: 1931647

Summary Related BioAssays by Target

Select item 193164320.

Inhibition of BH3 peptide binding to Bcl-2 (unknown origin)

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1931643

Summary Related BioAssays by Target

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BioAssays with compounds reported as validated chemical probes

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BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (77)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (236)
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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (327)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
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Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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BioAssays extracted from the literature
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BioAssays deposited by the NIH Molecular Libraries Program
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