Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19635091.

Homogeneous Time-Resolved Fluorescence (HTRF) Binding Assay from US Patent US20240083890: "MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1"

Source:: BindingDB

Protein Targets:: Induced myeloid leukemia cell differentiation protein Mcl-1; ...
Total:: 1

Assay data:31 Active, 27 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested

AID:: 1963509

Summary Related BioAssays by Target

Select item 19634782.

homogeneous time-resolved fluorescence (HTRF) binding assay from US Patent US20240067660: "MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS"

Source:: BindingDB

Protein Targets:: Induced myeloid leukemia cell differentiation protein Mcl-1; ...
Total:: 1

Assay data:36 Active, 25 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested

AID:: 1963478

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19629903.

Caspase Glo MOLP-8 assay

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1962990

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19629894.

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:1 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1962989

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19571625.

Inhibition of N-terminal GST-tagged human recombinant Mcl-1 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:26 Active, 17 Activity ≤ 1 µM, 29 Tested

AID:: 1957162

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19571616.

Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as dissociation constant by SPR analysis

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:16 Active, 12 Activity ≤ 1 µM, 17 Tested

AID:: 1957161

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19571607.

Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as binding constant (Kon) by SPR analysis

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:9 Tested

AID:: 1957160

Summary PubMed Citation Related BioAssays by Target

Select item 19571598.

Binding affinity to N-terminal his6-tagged human recombinant Mcl-1 expressed in Escherichia coli assessed as binding constant (Koff) by SPR analysis

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:9 Tested

AID:: 1957159

Summary PubMed Citation Related BioAssays by Target

Select item 19571589.

Inhibition of his-tagged human recombinant Bcl-2 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay

Source:: ChEMBL

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 2

Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested

AID:: 1957158

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193922110.

Binding affinity to Mcl-1 (unknown origin)

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1939221

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193922011.

Inhibition of TAMRA-labeled BIM-BH3 peptide binding to 6His-tagged human recombinant Mcl-1 (171 to 327 residues) incubated for 120 mins by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1939220

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193921812.

Inhibition of FITC-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939218

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193921713.

Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) incubated for 20 mins by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939217

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193921114.

Inhibition of fluorescent-labeled BID-BH3 peptide binding to Mcl-1 (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939211

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193834615.

Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant Mcl-1 (unknown origin) by fluorescence polarization-based competitive binding assay

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1938346

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193834016.

Inhibition of Mcl-1 (unknown origin)

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1938340

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193833417.

Inhibition of Bfl-1/Bim (unknown origin) incubated for 30 mins by TR-FRET assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 2 Tested

AID:: 1938334

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 193833318.

Inhibition of Bfl-1/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1938333

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193833219.

Inhibition of Bfl-1/Bim (unknown origin) by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Bcl-2-like protein 11; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1938332

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193787420.

Displacement of fluorescein tagged Bak BH3 peptide from MCL-1 (172 to 327 residues) (unknown origin) by fluorescence polarization competition assay

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:1 Active, 1 Tested

AID:: 1937874

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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BioAssays with protein sequences specified as targets

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BioAssays with compounds reported as validated chemical probes

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Activity (IC50, etc) ≤ 1 nM (69)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (264)
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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (346)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
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Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (534)
BioAssays extracted from the literature
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BioAssays deposited by the NIH Molecular Libraries Program
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BioAssays deposited by other experimentalists

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