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Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Serotonin (5-Hydroxytryptamine) 5-HT2B Eurofins Panlabs panel
5HT2B/H AG Eurofins SafetyScreen44 (BI)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration
Assay data:13 Active, 9 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:103 Active, 70 Activity ≤ 1 µM, 317 Tested
Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:147 Active, 45 Activity ≤ 1 µM, 1167 Tested
Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method
Assay data:3 Active, 5 Activity ≤ 1 µM, 927 Tested
Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader
Assay data:17 Active, 10 Activity ≤ 1 µM, 1196 Tested
Inhibition of 5-HT2B receptor (unknown origin) upto 10000 nM
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor at 10 uM after 60 mins by scintillation counting analysis relative to control
Assay data:3 Tested
Antagonist activity at human 5-HT2B receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
Binding affinity to 5-HT2B (unknown origin) assessed as equilibrium binding constant
Assay data:11 Active, 11 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
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