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5-HT2C Receptor Binding Inhibition Assay from US Patent US20240083872: "CYCLIC AMINE DERIVATIVES HAVING SEROTONIN RECEPTOR BINDING ACTIVITY"
Assay data:114 Active, 11 Activity ≤ 1 nM, 101 Activity ≤ 1 µM, 114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Serotonin (5-Hydroxytryptamine) 5-HT2C Eurofins Panlabs panel
Binding affinity towards human HTR2C in an in vitro assay with cellular components measured by radioactivity method
Assay data:123 Active, 1 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 1199 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of 5-HT2C receptor (unknown origin) upto 10000 nM
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at 5-HT2CR (unknown origin) stably expressed in HEK293 cells at 30 to 100 uM measured after 1 hr by fluorescence based Ca2+/Fluo-4 assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at 5-HT2CR (unknown origin) stably expressed in HEK293 cells assessed as maximal response measured after 1 hr by fluorescence based Ca2+/Fluo-4 assay relative to control
Assay data:4 Tested
Agonist activity at 5-HT2CR (unknown origin) stably expressed in HEK293 cells at 10 to 100 uM measured after 1 hr by fluorescence based Ca2+/Fluo-4 assay
Assay data:2 Active, 2 Tested
Agonist activity at 5-HT2CR (unknown origin) stably expressed in HEK293 cells measured after 1 hr by fluorescence based Ca2+/Fluo-4 assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to 5-HT2C (unknown origin) assessed as inhibition constant
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]-LSD from human 5-HT2C expressed in human HEK cells assessed as inhibition constant by FLIPR assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Displacement of [3H]-ketanserin from rat 5-HT2C expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Binding affinity to 5HT2C receptor (unknown origin) assessed as inhibition constant
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of 5HT2C receptor (unknown origin) at 10 uM
Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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