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SPR Binding Assay from US Patent US20240166598: "COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THE SAME"
Assay data:70 Active, 29 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
SARS-CoV-2, SARS-CoV-1, MERS, 0C43 and 229E Mpro Biochemical Protease Activity Assay from US Patent US20240158368: "Pyrrolidine Main Protease Inhibitors as Antiviral Agents"
Assay data:85 Active, 71 Activity ≤ 1 nM, 85 Activity ≤ 1 µM, 85 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Assay (Cruzain) from US Patent US20240150396: "INHIBITORS OF CYSTEINE PROTEASES"
Assay data:35 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 36 Tested
Enzymatic Assay for Mpro from US Patent US20240131036: "COMPOSITIONS AND METHODS OF TREATING CONDITIONS"
Assay data:7 Active, 3 Activity ≤ 1 µM, 7 Tested
Mpro In Vitro Screening Assay from US Patent US11963959: "Inhibitors for coronavirus"
Assay data:12 Active, 9 Activity ≤ 1 µM, 12 Tested
SARS-CoV-2 3C-like (3CL) protease fluorescence assay (FRET) from US Patent US11912714: "Spiropyrrolidine derived antiviral agents"
Assay data:47 Active, 48 Activity ≤ 1 µM, 48 Tested
Measuring Antiviral Effect of Compounds from US Patent US11905306: "Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus"
Assay data:70 Active, 38 Activity ≤ 1 µM, 80 Tested
Antiviral Assay from US Patent US20240043417: "COMPOUNDS FOR THE TREATMENT OF SARS"
Assay data:1 Active, 19 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
SARS-CoV-2 3CLpro Enzyme Assay from US Patent US20240043417: "COMPOUNDS FOR THE TREATMENT OF SARS"
Assay data:11 Active, 23 Tested
Antiviral Assay from US Patent US20240034730: "PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SARS-CoV-2 Plaque Assay 2 from US Patent US20240033256: "INHIBITORS OF POSITIVE STRAND RNA VIRUSES"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SARS-CoV-2 Plaque Assay 1 from US Patent US20240033256: "INHIBITORS OF POSITIVE STRAND RNA VIRUSES"
SARS-CoV-2 Immunofluorescence Assay 2 from US Patent US20240033256: "INHIBITORS OF POSITIVE STRAND RNA VIRUSES"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SARS-CoV-2 Immunofluorescence Assay 1 from US Patent US20240033256: "INHIBITORS OF POSITIVE STRAND RNA VIRUSES"
Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by FRET at 1mM DTT.
Assay data:24 Active, 19 Activity ≤ 1 µM, 64 Tested
Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by FRET.
Assay data:33 Active, 20 Activity ≤ 1 µM, 64 Tested
Inhibition of recombinant SARS-CoV-2 main protease using Dabcyl-KTSAVLQSGFRKM-E(Edans-NH2) as substrate preincubated for 15 mins followed by substrate addition by FRET analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant SARS-CoV-2 main protease expressed in Escherichia coli BL21 using Dabcyl-EDANS and Boc-Abu-Tle-Leu-Gln-AMC as substrate
Inhibition of SARS-CoV-2 RdRP using ATP substrate preincubated with compound for 30 mins followed by substrate addition and measured after 30 mins by Alphascreen microplate reader analysis
Assay data:2 Active, 2 Tested
Inhibition of MBP tagged recombinant SARS-CoV-2 main protease using DABCYL-KTSAVLeu(13C6,15N)-Q as substrate incubated for 2 to 3 hrs by mass spectrometric analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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