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Inhibition of M-1 water resorption
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of Na+ current by Ussing Chamber
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of S3969-stimulated ENaCalpha beta gamma (unknown origin) transfected in HEK293 cells at 10 uM measured after 5 mins by FLIPR assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of S-3969-stimulated recombinant human ENaC alpha subunit expressed in HEK293 cells at 10 uM preincubated for 5 mins followed by S-3969 stimulation by FLIPR assay
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp based Ussing chamber assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Late-stage counterscreen panel assay for AVPR1a antagonists: Panlabs HitProfilingScreen
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of human ENaC alpha-beta-gamma expressed in Xenopus laevis oocytes assessed as effect on transmembrane currents at 100 uM by two-electrode voltage-clamp technique
Assay data:1 Tested
Inhibition of human ENaC alpha-beta-gamma expressed in Xenopus laevis oocytes assessed as effect on transmembrane currents at 1 mM by two-electrode voltage-clamp technique
Assay data:5 Tested
Late-stage counterscreen panel assay for S1P3 agonists: Ricerca HitProfilingScreen + CYP450
Late-stage counterscreen panel assay for GPR7 antagonists: Ricerca HitProfilingScreen + CYP450: Set 2
Late-stage counterscreen panel assay for S1P4 agonists: Ricerca HitProfilingScreen + CYP450: Set 2
Late-stage counterscreen panel assay for GPR7 antagonists: Ricerca HitProfilingScreen + CYP450
Late-stage counterscreen panel assay for S1P4 agonists: Ricerca HitProfilingScreen + CYP450
Counterscreen panel assay for S1P4 antagonists: Ricerca HitProfilingScreen + CYP450
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay
Assay data:42 Active, 42 Activity ≤ 1 µM, 42 Tested
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