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Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Transporter, Serotonin (5-Hydroxytryptamine) (SERT) Eurofins Panlabs panel
SLC6A4/H Eurofins SafetyScreen44 (BI)
Binding affinity towards human SLC6A4 in an in vitro assay with cellular components measured by scintillation counting
Assay data:148 Active, 75 Activity ≤ 1 µM, 1194 Tested
Assay data:99 Active, 36 Activity ≤ 1 µM, 927 Tested
Inhibition of SERT (unknown origin) upto 10000 nM
Displacement of [3H]-imipramine from recombinant human 5-HT transporter at 10 uM after 60 mins by scintillation counting relative to control
Assay data:3 Tested
Inhibition of SERT (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of SERT in human platelet rich plasma assessed as inhibition of 5-HT reuptake by measuring absorbance at 100 ng/ml preincubated for 10 mins followed by 5-HT addition and measured after 10 mins by ELISA analysis
Assay data:14 Tested
Inhibition of SERT (unknown origin) at 10 uM
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
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