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Fluorometric Assay (Inhibition of 4MU-B cleavage)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryRelated BioAssays by Target
Cellular GlcCer reduction
Mouse GCS enzymatic assay
Human GCS enzymatic assay
Inhibition of GSG in mouse MEB5 cells
Assay data:1 Active, 2 Tested
Inhibition of GCS in human iPSC derived neurons assessed as reduction in brain GlcCer levels
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Invivo inhibition of GCS in C57 mouse assessed as reduction in brain GlcCer d18:1/18:0 concentration measured after 8 hrs by LC-MS/MS method
Invivo inhibition of GCS in C57 mouse assessed as reduction in brain GlcCer d18:1/18:0 concentration at 30 to 100 mg/kg, po measured after 8 hrs by LC-MS/MS method
Assay data:1 Active, 1 Tested
Inhibition of GCS in mouse fibroblast
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of GCS in human fibroblast
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of Glucosylceramide synthase (unknown origin) using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by UDP-Glo luminometer analysis
Assay data:8 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 12 Tested
UDP-Glo Glucosylceramide Synthase Biochemical Assay from US Patent US20240018140: "MODIFIED IMIDAZOPYRIDINES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS"
Assay data:83 Active, 14 Activity ≤ 1 nM, 83 Activity ≤ 1 µM, 83 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
UDP-Glo Glucosylceramide Synthase Biochemical Assay from US Patent US20230391758: "MODIFIED BENZOFURAN-CARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS"
Assay data:39 Active, 21 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 39 Tested
Inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hrs by Rapidfire mass spectrometric analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hrs by Rapidfire mass spectrometric analysis
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measured after 20 hrs by UDP-Glo glucosylceramide synthase based luminometer analysis
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of GCS in GBA mutant human fibroblasts assessed as reduction in glucosylceramide level incubated for 4 days by RapdiFire-MS/MS analysis
Uncompetitive inhibition of GCS (unknown origin) using 1 to 70 uM C8-ceramide and 0.1 to 200 uM UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Non-competitive inhibition of GCS (unknown origin) using 1 to 70 uM C8-ceramide and 0.1 to 200 uM UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry
Inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry
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