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Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of AhR (unknown origin) upto 10000 nM
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human AHR in HEK293 cells assessed as nuclear translocation over cytosol incubated for 45 mins by Hoechst staining based assay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of human AhR
Activation of rat AhR
Agonist activity at EGFP-tagged human AhR transfected in HEK293 cells assessed as induction of nuclear translocation incubated for 45 mins by fluorescence based assay
Antagonist activity at AhR in human HepG2 cells assessed as inhibition of TCDD-induced receptor activation pretreated for 1 hr followed by TCDD addition and measured after 24 hrs by bright-glo luciferase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at AhR (unknown origin) assessed as inhibition of receptor activation
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Modulator activity at AhR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Antagonist activity at AhR (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of TCDD binding to rat liver cytosol AhR
Antagonist activity at AhR in rat liver cytosol assessed as inhibition of TCDD-induced AhR/DNA complex formation by gel retardation assay
Antagonist activity at AhR (unknown origin) assessed as inhibition of TCDD-induced luciferase activity
Antagonist activity at AhR (unknown origin) expressed in human U87 cells assessed as inhibition of kynurenic acid-induced transactivation by Renilla/Firefly based dual-glo luciferase assay
Binding affinity to AhR (unknown origin) assessed as inhibition constant
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Activation of human AhR expressed in Saccharomyces cerevisiae YCM3 coexpressing ARNT incubated for 18 hrs
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Agonist activity at AhR (unknown origin)
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Binding affinity to AhR (unknown origin) assessed as dissociation constant
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Binding affinity to AhR (unknown origin)
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