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SARM1 NADase ADPR production from US Patent US11903935: "Inhibitors of SARM1 NADase activity and uses thereof"
Assay data:3 Active, 4 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
SARM1 NADase HPLC-Based Assay 2 from US Patent US11903935: "Inhibitors of SARM1 NADase activity and uses thereof"
ARM-SAM-TIR SARM1 IC50 Assay from US Patent US20240051939: "BENZOPYRAZOLE INHIBITORS OF SARM1"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
n Vitro Biochemical Test of Inhibiting SARM1 Enzyme Activity Assay from US Patent US20230414581: "SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF IN NEURODEGENERATIVE DISEASES"
Assay data:10 Active, 8 Activity ≤ 1 µM, 14 Tested
Enzymatic Assay from US Patent US20230286978: "INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1"
Assay data:12 Active, 11 Activity ≤ 1 µM, 13 Tested
Biological Assay from US Patent US11629136: "Substituted pyridine derivatives as SARM1 inhibitors"
Assay data:42 Active, 20 Activity ≤ 1 µM, 57 Tested
ARM-SAM-TIR IC50 Assay from US Patent US20230271957: "CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1"
Assay data:19 Active, 18 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of purified human SARM1 TIR domain (561 to 724 residues) using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Expi293 cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr
Inhibition of recombinant human SARM1 SAM1-2-TIR domains (412 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr
Competitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed as EADPR formation using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr
Noncompetitive inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates assessed as EADPR formation using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 1 hr
Assay data:3 Tested
Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate preincubated for 20 mins followed by ENAD addition and measured at 15 sec interval for 15 mins
Assay data:4 Tested
Inhibition of recombinant human SARM1 TIR domain (561 to 724 residues) expressed in Escherichia coli C43 (DE3) cells lysates using ENAD as substrate at 25 uM preincubated for 20 mins followed by ENAD addition and measured after 1 hr relative to control
Inhibition of SARM1 in CD1 mouse DRG cells assessed as inhibition of axon degeneration measured during 6 to 24 hrs by SEM micrography
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of SARM1 in CD1 mouse DRG cells assessed as inhibition of axon degeneration measured during 6 to 24 hrs by drop culture assay
Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring ADPR production at 150 uM pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis
Assay data:6 Tested
SummaryRelated BioAssays by Target
Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring NAD consumption at 150 uM pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis relative to control
Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring maximal ADPR conversion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis
Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring NAD depletion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis
Assay data:5 Active, 2 Activity ≤ 1 µM, 6 Tested
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