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P. falciparum growth and inhibition assays from US Patent US11903936: "Anti-malarial agents"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
DHODH Kinetic Analysis from US Patent US11903936: "Anti-malarial agents"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
hDHODH inhibition assay from US Patent US20240034730: "PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS"
Assay data:40 Active, 2 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 45 Tested
Inhibition of DHODH in human HeLa cells assessed as reduction in hypoxia-induced VEGF expression incubated for 48 hrs by ELISA assay
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human DHODH
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human recombinant DHODH expressed in Escherichia coli BL21(DE3) cells by microplate reader analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
In Vitro Assay 2 from US Patent US11713304: "2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH"
Assay data:57 Active, 1 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 70 Tested
In Vitro Assay 1 from US Patent US11713304: "2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH"
Assay data:195 Active, 1 Activity ≤ 1 nM, 175 Activity ≤ 1 µM, 199 Tested
In Vitro Assay: DHODH Enzymatic Assay from US Patent US11505536: "Dihydroorotate dehydrogenase inhibitors"
Assay data:137 Active, 41 Activity ≤ 1 nM, 134 Activity ≤ 1 µM, 138 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (Measles Virus Inhibition Assay) EUB0000745a DHODH
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of rat DHODH
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of mouse DHODH
Binding affinity to His fused human DHODH expressed in Escherichia coli assessed as dissociation half life by surface plasmon resonance assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to His fused human DHODH expressed in Escherichia coli by surface plasmon resonance assay
Inhibition of His fused human DHODH expressed in Escherichia coli using DHO as substrate by DCIP absorbance based colorimetry assay
Assay data:29 Active, 7 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 29 Tested
Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate reader analysis
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) at 100 nM using dihydroorotate as substrate by DCIP based microplate reader analysis relative to control
Assay data:39 Tested
Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) at 1 uM using dihydroorotate as substrate by DCIP based microplate reader analysis relative to control
Inhibition of DHODH (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
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