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CDC42 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
CDC42BPA SGC Tm panel (DSF)
Inhibition of Cdc42 in human HeLa cells by Flow cytometric G-trap effector binding assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Rac1 in human HeLa cells by Flow cytometric G-trap effector binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Rac1 in human HPAF-II cell
Assay data:1 Active, 2 Tested
Inhibition of Cdc42 GTPase in human breast cancer cell line treated for 24 hrs by western blot assay
Inhibition of Rac1 GTPase in human breast cancer cell line treated for 24 hrs by western blot assay
Inhibition of Rac1 GTPase in human MDA-MB-231 cells assessed as inhibition of cell proliferation treated for 72 hrs by MTT assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Rac1 GTPase in human MDA-MB-435 cells
Inhibition of CDC42 delta (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:12 Tested
Inhibition of Rac1 activation in mouse NIH/3T3 cells lysates pre-incubated for 1 hr before addition of Rac activator stimulation by immunoblot analysis based pull-down assay relative to control
Assay data:10 Active, 8 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Rac1 in mouse airways smooth muscle cells assessed as reduction in methacholine-induced maximal contraction pre-incubated for 1 hrs before methacholine addition
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of Rac1 in mouse NIH/3T3 cells assessed as reduction in Rac activator-stimulated cell migration incubated for 24 hrs
Assay data:2 Active, 2 Tested
Inhibition of Rac1 in mouse NIH/3T3 cells assessed as reduction in Rac activator-stimulated cell adhesion measured every 5 mins for 6 hrs by xCELLigence assay
Inhibition of Rac1 in mouse NIH/3T3 cells assessed as reduction in Rac activator-stimulated membrane ruffling
Assay data:2 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of mouse RhoG assessed as decrease in B-max for GTP-binding on Rac1 by mant-GTP binding kinetics real-time assay
Inhibition of mouse Rac2 assessed as decrease in B-max for GTP-binding on Rac1 by mant-GTP binding kinetics real-time assay
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