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Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b GRIN1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Panel of non-epigenetic targets (kinases, GPCRs, ion channels, and transporters, Eurofins) ) EUB0000271b GRIN1
Selectivity interaction (Panel of kinases, GPCRs, ion channels and transporters (enzymatic assay)) EUB0000223bCl GRIN2B
Selectivity interaction (Panel of kinases, GPCRs, ion channels and transporters (enzymatic assay)) EUB0000223bCl GRIN1
Selectivity interaction (Panel of kinases, GPCRs, ion channels and transporters (enzymatic assay)) EUB0000266bCl GRIN2B
Selectivity interaction (Panel of kinases, GPCRs, ion channels and transporters (enzymatic assay)) EUB0000266bCl GRIN1
Inhibition of Glutamate, NMDA, Glycine at 10.0 M in the Eurofins Panlabs Safety Screen
Inhibition of Glutamate, NMDA, Agonism at 10.0 M in the Eurofins Panlabs Safety Screen
Activity against NMDAPHSI/R in the Eurofins Panlabs screen (BI) by Radioactive Assay
Activity against NMDAGLSI/R in the Eurofins Panlabs screen (BI) by Radioactive Assay
Agonist activity in the Eurofins Panlabs screen (BI) against NMDAAGSI/R by Radioactive Assay
Activity against PCP/R in the Eurofins SafetyScreen44 (BI) by Radioactive Assay (Old_Cerep_32)
Inhibitor of NMDA/R in the Eurofins SafetyScreen44 (CEREP) (BI) by Radioactive Assay (Cerep_66)
Assay data:4 Tested
SafetyScreen: Glutamate (NMDA, Non-Selective) Rat Ion Channel [3H] CGP-39653 Binding LeadHunter Assay, catalogue number: 66
Assay data:10 Tested
Positive allosteric modulation of GluN1/N2A in glutamate-induced excitotoxicity rat PC12 cell model assessed as increase in CREB phosphorylation at Ser133 at 1 uM measured after 24 hrs in presence of NVP-AAM077 by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of GluN1/N2A in glutamate-induced excitotoxicity rat PC12 cell model assessed as increase in CREB phosphorylation at Ser133 at 1 uM measured after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Negative allosteric modulation of GluN1/N2B (unknown origin) transfected in HEK293 cells assessed as potentiation of Glu/Gly-induced calcium influx by Cal-520 AM dye based assay
Positive allosteric modulation of GluN1/N2A/N2B (unknown origin) transfected in HEK293 cells assessed as potentiation of Glu/Gly-induced calcium influx by Cal-520 AM dye based assay
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