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Determination of Related Protease Inhibition from US Patent US20240059691: "ENZYME INHIBITORS"
Assay data:279 Active, 16 Activity ≤ 1 nM, 253 Activity ≤ 1 µM, 299 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Thrombin Serine protease panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Compound was evaluated for inhibition of human F2 in an in vitro cell free assay measured by fluorescence spectroscopy
Assay data:11 Active, 8 Activity ≤ 1 µM, 927 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of thrombin (unknown origin)
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human thrombin at 500 uM by chromogenic substrate hydrolysis assay
Assay data:27 Tested
Inhibition of human thrombin at 5 uM using Boc-VPR-MCA as substrate relative to control
Assay data:2 Tested
Inhibition of human thrombin using Boc-VPR-MCA as substrate
Assay data:3 Tested
Inhibition of human thrombin by fluorescence based analysis
Inhibition of human thrombin using Z-GGR-AMC as substrate assessed as inhibition constant by fluorescence plate reader analysis
Inhibition of human thrombin
Assay data:5 Tested
Inhibition of thrombin (unknown origin) using CH3SO2-dCha-Gly-Arg-pNA as substrate by fluorescence plate reader analysis
Enzymatic Activity Assay from US Patent US20230391761: "SUBSTITUTED S-ALANINATE DERIVATIVES"
Assay data:17 Active, 14 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Activity Assay from US Patent US11584735: "Solid forms of a plasma kallikrein inhibitor and salts thereof"
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic Assay for Thrombin from US Patent US11584714: "MASP-2 inhibitors and methods of use"
Assay data:255 Active, 142 Activity ≤ 1 µM, 453 Tested
Selectivity interaction (Serine protease panel) EUB0000735a F2
Inhibition of bovine thrombin at 100 uM using Tos-Gly-Pro-Arg-AMC as substrate by fluorescence plate reader analysis
Assay data:9 Tested
Inhibition of human plasma thrombin at 100 uM using Z-Gly-Pro-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by based spectrofluorimetric method
Inhibition of human plasma thrombin using Z-Gly-Pro-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by based spectrofluorimetric method
Inhibition of native full length human thrombin using Boc-Asp(OBz1)-Pro-Arg-AMC as substrate at 5 uM incubated for 30 mins followed by substrate addition by fluorescence based analysis
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