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Competitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
Assay data:16 Active, 2 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to CCR7 (unknown origin) at 10 uM by radioligand binding assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human CCR7 at 10 uM relative to control
Antagonist activity against CCR7 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CCR7 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
PRESTO-Tango GPCRome screening (CCR7)
SummaryRelated BioAssays by Target
Antagonist activity at CCR7 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM
Antagonist activity at human Gi/G0-coupled CCR7 receptor assessed as inhibition of CCL19-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by CCL19 stimulation and measured after 90 to 180 mins by pathhunter assay
Inhibition of CCR7 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at CCR7 (unknown origin) at 10 uM
Assay data:3 Tested
Antagonist activity at human CCR7 expressed in CHOK1 cells assessed as inhibition of CCL19-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins
Antagonist activity at CCR7 (unknown origin)
Agonist activity at CCR7 (unknown origin)
Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay
Assay data:1 Active, 6 Tested
Mouse CCR7 (Chemokine receptors)
Assay data:3 Active, 3 Tested
Human CCR7 (Chemokine receptors)
Inhibition of CCR7 (unknown origin) at 10 uM relative to control
Antagonist activity at CCR7 in human CCRF-CEM cells assessed as inhibition of MIP-3beta-induced calcium flux at 5 uM preincubated for 15 mins by spectrophotometric analysis relative to control
Assay data:5 Tested
Binding affinity to CCR7 (unknown origin) at 10 uM by radioligand displacement assay
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