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Patch clamp assay from US Patent US20240190865: "T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF"
Assay data:53 Active, 40 Activity ≤ 1 µM, 57 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Safety47 Scan (DiscoverX - Eurofins)
Calcium Channel L-Type, Dihydropyridine Eurofins Panlabs panel
Calcium Channel L-Type, Benzothiazepine Eurofins Panlabs panel
CA+/DHPSI/R Eurofins SafetyScreen44 (BI)
Compound was evaluated for inhibition of human CACNA1C in an in vitro cell-based assay measured by IonWorks automated patch clamp
Assay data:14 Active, 3 Activity ≤ 1 µM, 116 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for inhibition of rat Cacna1c in an in vitro assay with cellular components measured by membrane filtration
Assay data:31 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 943 Tested
Compound was evaluated for inhibition of rat Cacna1b in an in vitro assay with cellular components measured by membrane filtration
Assay data:1 Active, 314 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Cav1.2 channel (unknown origin) upto 10000 nM
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]D 888 from rat brain L-type calcium channel verapamil binding site at 10 uM after 120 mins by scintillation counting analysis relative to control
Assay data:3 Tested
Inhibition of Cav1.2 (unknown origin) at 10 uM
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