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Binding Assay from US Patent US8906933: "Dihydropyrimidin-2(1H)-one compounds as neurokinin-3 receptor antagonists"
Assay data:19 Active, 16 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
GSNOR Assay from US Patent US8741915: "Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors"
Assay data:21 Active, 17 Activity ≤ 1 µM, 23 Tested
Binding affinity to Alcohol dehydrogenase class-3 in human MDA-MB-468 cells at 10 uM incubated for 2 hrs in presence of 12-amino-2-[4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-indole-2-carbonyl)amino]-2-hydroxy-ethyl]phenyl]sulfonyl-dodecanoic acid by quantitative chemical proteomics assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to Alcohol dehydrogenase class-3 in human MDA-MB-468 cells at 10 uM incubated for 2 hrs in presence of 2-[4-[(1S)-1-[[6-(10-aminodecyl)-4,5-dichloro-1-methyl-indole-2-carbonyl]amino]-2-hydroxy-ethyl]phenyl]sulfonylacetic acid by quantitative chemical proteomics assay
Inhibition of ADH1 (unknown origin) preincubated for 2 hrs followed by substrate/NAD+ addition
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ADH1B (unknown origin) assessed as reduction in NADH production by spectrophotometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of rat GSNOR assessed as reduction in NADH consumption after 3 mins by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of mouse GSNOR assessed as reduction in NADH consumption after 3 mins by spectrophotometric analysis
Inhibition of human GSNOR assessed as reduction in NADH consumption at 10 uM after 3 mins by spectrophotometric analysis relative to control
Assay data:5 Tested
Inhibition of human GSNOR assessed as reduction in NADH consumption after 3 mins by spectrophotometric analysis
Assay data:39 Active, 38 Activity ≤ 1 µM, 39 Tested
Reversible inhibition of horse liver alcohol dehydrogenase using ethanol as substrate assessed as reduction in enzyme activity at 1 mM by stopped-flow method in presence of 1 mM NAD+
Assay data:2 Tested
Reversible inhibition of horse liver alcohol dehydrogenase using ethanol as substrate assessed as reduction in enzyme activity at 0.1 mM compound in diluted assay mixture measured after 20 to 40 mins by stopped-flow method in presence of NAD+
Assay data:3 Tested
Reversible inhibition of horse liver alcohol dehydrogenase using ethanol as substrate assessed as increase in enzyme activity at 1 mM measured after 40 mins of 100-fold dilution by stopped-flow method in presence of NAD+
Reversible inhibition of horse liver alcohol dehydrogenase using ethanol as substrate at 1 mM measured after 100-fold dilution by stopped-flow method in presence of NAD+
Reversible inhibition of horse liver alcohol dehydrogenase using ethanol as substrate by stopped-flow method in presence of 1 mM NAD+
Inactivation of horse liver alcohol dehydrogenase using ethanol as substrate at 10 to 200 mM up to 5 mins by spectrophotometric titration in presence of 1 mM NAD+
Inactivation of horse liver alcohol dehydrogenase using ethanol as substrate at 200 mM up to 5 mins by spectrophotometric titration
Inactivation of horse liver alcohol dehydrogenase using ethanol as substrate at 10 mM up to 5 mins by spectrophotometric titration
Competitive inhibition of horse liver alcohol dehydrogenase using ethanol as substrate by spectrophotometric titration in presence of 1 mM NAD+
Assay data:9 Active, 9 Tested
Inhibition of horse liver alcohol dehydrogenase using ethanol as substrate assessed as dissociation constant by spectrophotometric titration in presence of 1 mM NAD+
Assay data:7 Active, 5 Activity ≤ 1 µM, 15 Tested
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