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Inhibition of CAD (unknown origin) CSP2 activity expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins followed by ATP addition measured after 60 mins by ADP-Glo assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CAD in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to CAD in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay
Compound was evaluated for the inhibition of dihydroorotase enzyme from mouse Ehrlich ascites at the concentration of 10 uM and at pH 7.37
Assay data:5 Tested
Kinetic constant for the inactivation of Dihydroorotase (DHO) at pH 6.0
Kinetic constant for the inactivation against Dihydroorotase (DHO) at a concentration of 3 uM
Inhibitory activity against dihydroorotase isolated from 165-23 cells of Syrian hamster kidney cells at a concentration of 0.1-1000 uM; No effect
Assay data:4 Tested
Inhibitory activity against Dihydroorotase (DHO) at pH 7.4 and 8.5
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibitory activity against Dihydroorotase (DHO) at pH 6.0
Compound ability to inhibit the catalytic activity of hamster Dihydroorotase (DHOase) expressed in Escherichia coli.
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibitory activity against Dihydroorotase (DHO); no reproducible apparent Ki data
Inhibitory activity against Dihydroorotase (DHO) using CAD protein at concentrations >=6 mM; no inhibition was observed
Compound was evaluated for its effect on the activity of mammalian Carbamoyl-phosphate synthetase in the multienzyme polypeptide CAD at a concentration of 1.2 mM
SummaryRelated BioAssays by Target
Compound was evaluated for its effect on the activity of mammalian Carbamoyl-phosphate synthetase in the multienzyme polypeptide CAD at a concentration of 4mM
Compound was evaluated for its effect on the activity of mammalian Carbamoyl-phosphate synthetase in the multienzyme polypeptide CAD at a concentration of 1.6mM
Assay data:2 Tested
Compound was evaluated for its effect on the activity of mammalian Carbamoyl-phosphate synthetase in the multienzyme polypeptide CAD at a concentration of 1.2mM
Assay data:3 Tested
Compound was evaluated for its effect on the activity of mammalian Carbamoyl-phosphate synthetase in the multienzyme polypeptide CAD at a concentration of 0.4mM
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