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Biochemical Kinase Assay Protocol (JAK) from US Patent US20240132525: "BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF"
Assay data:90 Active, 39 Activity ≤ 1 nM, 91 Activity ≤ 1 µM, 91 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzymatic Inhibitory Activity Assay from US Patent US20240132489: "AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:55 Active, 55 Activity ≤ 1 µM, 55 Tested
Activity Inhibition Assay on CDK Family Kinases from US Patent US20240109898: "SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF"
Assay data:84 Active, 83 Activity ≤ 1 µM, 84 Tested
ADP-Glo Kinase Assay from US Patent US20240109890: "BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
CDK2/Cyclin E1 Full Length ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:111 Active, 104 Activity ≤ 1 µM, 122 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
CDK1/Cyclin B1 ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:83 Active, 59 Activity ≤ 1 µM, 122 Tested
Biochemical JAK Kinase Assays from US Patent US20240092758: "IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS"
Assay data:392 Active, 381 Activity ≤ 1 nM, 392 Activity ≤ 1 µM, 392 Tested
EGFR Kinase Assay from US Patent US20240083857: "2-Methyl-Quinazolines"
Assay data:5 Active, 2 Activity ≤ 1 µM, 301 Tested
CDK2/Cyclin E1 HTRF Enzyme Activity Assay from US Patent US11919904: "Sulfonylamide compounds as CDK2 inhibitors"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
In Vitro JAK Kinase Assay from US Patent US11918581: "Combination therapy comprising JAK pathway inhibitor and rock inhibitor"
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
FRET based assay from US Patent US11912660: "S6K1 protein kinase inhibitors as cancer therapeutics"
Assay data:2 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
In Vitro JAK Kinase Assay from US Patent US20240058343: "TREATMENT OF URTICARIA USING JAK INHIBITORS"
TBD from US Patent US20240034743: "TRICYCLIC COMPOUNDS AS EGFR INHIBITORS"
Assay data:135 Active, 118 Activity ≤ 1 nM, 137 Activity ≤ 1 µM, 137 Tested
Assay data:133 Active, 31 Activity ≤ 1 nM, 137 Activity ≤ 1 µM, 137 Tested
CDK2/Cyclin E1 Full length ADP-Glo Kinase Assay from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:95 Active, 92 Activity ≤ 1 µM, 97 Tested
CDK1/Cyclin B1 ADP-Glo Kinase Assay from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:75 Active, 1 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 99 Tested
Assay for Inhibition of CDK2/CyclinE1 from US Patent US20240033264: "CDK INHIBITORS"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
NanoBRET assay (JAK1, SGC Frankfurt)
Assay data:2 Tested
SummaryRelated BioAssays by Target
NanoBRET (AKT3)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
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