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Inhibition of human TRPML3-YFP expressed in HEK293 cells stimulated with ML-SA1 for 200 secs followed by incubation for 200 secs with compound and measured by Fura-2AM dye based single cell Calcium imaging assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human TRPML3-YFP expressed in HEK293 cells at 10 uM stimulated with ML-SA1 for 200 secs followed by incubation for 200 secs with compound and measured by Fura-2AM dye based single cell Calcium imaging assay
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of human TRPML3-YFP expressed in HEK293 cells incubated for 10 mins by Fluo-4 dye calcium imaging based FLIPR analysis
Assay data:5 Active, 15 Tested
Inhibition of human TRPML3-YFP expressed in HEK293 cells preincubated for 10 mins followed by stimulation with ML-SA1 and measured after 10 mins by Fluo-4 dye calcium imaging based FLIPR analysis
Assay data:15 Tested
Activation of human TRPML3-YFP expressed in HEK293 cells at 10 uM incubated for 200 secs with compound and measured by Fura-2AM dye based single cell Calcium imaging assay
Assay data:4 Active, 4 Tested
Human TRPML3 (Transient Receptor Potential channels)
Assay data:5 Active, 5 Tested
Mouse TRPML3 (Transient Receptor Potential channels)
Assay data:1 Active, 1 Tested
Late stage results from the probe development efforts to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3): fluorescence-based cell-based dose response assay for TRPML3 agonists (probe candidates and analogs, Round 3)
Assay data:12 Active, 2 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage results from the probe development efforts to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3): fluorescence-based cell-based dose response assay for TRPML3 agonists (probe candidates and analogs, Round 2)
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Late stage results from the probe development effort to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3): Fura-2 profiling assay
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage results from the probe development effort to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3): TRPML3 patch clamp assay
Late stage results from the probe development effort to identify selective agonists of the Transient Receptor Potential Channels 3 (TRPML3): fluorescence-based cell-based dose response assay for TRPML3 agonists
Assay data:6 Active, 2 Activity ≤ 1 µM, 6 Tested
Late stage results from the probe development efforts to identify agonists of the Transient Receptor Potential Channels 3 and 2 (TRPML3 and TRPML2).
Summary of probe development efforts to identify agonists of the transient receptor potential channel ML3 (TRPML3)
Assay data:2 Active, 2 Tested
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
Assay data:17 Active, 1 Activity ≤ 1 µM, 77 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
Assay data:136 Active, 8 Activity ≤ 1 µM, 188 Tested
Confirmation cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
Assay data:244 Active, 306 Tested
Counterscreen assay for TRPML3 agonists: cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1)
Assay data:40 Active, 306 Tested
Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
Assay data:632 Active, 218117 Tested
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