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Binding affinity towards human MC3R in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity towards human MC4R in an in vitro assay with cellular components measured by scintillation proximity assay in vitro assay with cellular components
Assay data:9 Active, 1 Activity ≤ 1 µM, 686 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:18 Active, 1 Activity ≤ 1 µM, 1213 Tested
Agonist activity at human melanocortin receptor 5 relative to control
Agonist activity at human melanocortin receptor 4 relative to control
Agonist activity at human melanocortin receptor 3 relative to control
Agonist activity at human melanocortin receptor 5
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at human melanocortin receptor 4
Agonist activity at human melanocortin receptor 3
Antagonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level at 0.1 to 0.000001 M in presence of 500 nM alpha-MSH by split luciferase cAMP sensor dynamic assay
Assay data:2 Tested
Agonist activity at human MC4R transfected in HEK293T cells co-transfected with GScAMP22F assessed as increase in cAMP level at 0.00001 to 10 uM by radioimmunoassay
Agonist activity at human MC3R transfected in HEK293T cells co-transfected with GScAMP22F assessed as increase in cAMP level at 0.00001 to 10 uM by radioimmunoassay
Agonist activity at human MC4R transfected in HEK293 cells assessed as cAMP accumulation
Displacement of [125I][Tyr2][Nle4-D-phe7]-alpha-mSH from to human MC3R expressed in BHK cell membrane incubated overnight in presence of protease inhibitor by SPA based radioligand competitive binding assay
Agonist activity at MC4R expressed in human U2OS cells assessed as increase in recruitment of beta-arrestin 2 level measured upto 0.00005 M by pathhunter express kit method
Agonist activity at MC3R expressed in human U2OS cells assessed as induction of beta-arrestin 2 recruitment upto 0.00005 M by measuring chemiluminescent signal
Agonist activity at human MC4R expressed in BHK cells assessed as increase in cAMP level measured upto 0.00005 M incubated for 30 mins by antibody based cAMP detection/FRET analysis
Agonist activity at human MC3R expressed in BHK cells assessed as increase in cAMP level measured upto 0.00005 M incubated for 30 mins by antibody based cAMP detection/FRET analysis
Antagonist activity at human MC5R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 500 nM alpha-MSH by split luciferase cAMP sensor dynamic assay
Antagonist activity at human MC4R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in presence of 70 nM alpha-MSH by split luciferase cAMP sensor dynamic assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
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